Project: HARMONIZATION OF ACQUISITION AND PROCESSING OF BRAIN IMAGING BIORMARKERS FOR NEURODEGENERATIVE DISEASES: A STRATEGIC RESEARCH AGENDA FOR BEST PRACTICE GUIDELINES

Acronym SRA-NED (Reference Number: JPCOFUND_FP-940-008)
Duration 01/10/2016 - 31/03/2017
Project Topic Background: Early and accurate diagnosis, prognosis, and tracking are still a challenge for the most prevalent neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Frontotemporal Dementia, and Huntington’s (AD, PD, FTD, HD). Much can be learned from multicentre longitudinal studies on molecular, functional, and structural neuroimaging biomarkers from PET, EEG, and MRI, but harmonization of image acquisition and processing remains challenging. Inadequate harmonisation prevents comparing data from different studies, delays the use of biomarkers in clinical research and drug discovery, leading to uneven and suboptimal quality of care and slowing of drug discovery. Aims: i) Identify critical factors challenging the large scale harmonization of multicentre clinical research neuroimaging studies (MRI, PET, EEG). This goal will be addressed by conducting a survey in expert centres. ii) Develop a strategic research agenda (SRA) providing a framework for addressing the most critical barriers for neuroimaging harmonization in large scale longitudinal multicentric studies. The SRA will help funding agencies to identify topics and actions deserving funding with the ultimate aim of developing best practice guidelines for biomarkers in neurodegenerative diseases. Workplan: Three subgroups of international experts will work on MRI, PET, and EEG neuroimaging markers, respectively. Based on the experience of international projects, an online questionnaire will be generated to evaluate the barriers to multicentre harmonization procedures in months 1-­‐2 (M1-­‐2). The survey will be addressed to imaging sites that are part of leading European AD, PD, FTD, and HD consortia (M3-­‐4). The survey will address hardware and software features, data quality control, data format, sharing and analyses pipelines. The Background: Early and accurate diagnosis, prognosis, and tracking are still a challenge for the most prevalent neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Frontotemporal Dementia, and Huntington’s (AD, PD, FTD, HD). Much can be learned from multicentre longitudinal studies on molecular, functional, and structural neuroimaging biomarkers from PET, EEG, and MRI, but harmonization of image acquisition and processing remains challenging. Inadequate harmonisation prevents comparing data from different studies, delays the use of biomarkers in clinical research and drug discovery, leading to uneven and suboptimal quality of care and slowing of drug discovery. Aims: i) Identify critical factors challenging the large scale harmonization of multicentre clinical research neuroimaging studies (MRI, PET, EEG). This goal will be addressed by conducting a survey in expert centres. ii) Develop a strategic research agenda (SRA) providing a framework for addressing the most critical barriers for neuroimaging harmonization in large scale longitudinal multicentric studies. The SRA will help funding agencies to identify topics and actions deserving funding with the ultimate aim of developing best practice guidelines for biomarkers in neurodegenerative diseases. Workplan: Three subgroups of international experts will work on MRI, PET, and EEG neuroimaging markers, respectively. Based on the experience of international projects, an online questionnaire will be generated to evaluate the barriers to multicentre harmonization procedures in months 1-­‐2 (M1-­‐2). The survey will be addressed to imaging sites that are part of leading European AD, PD, FTD, and HD consortia (M3-­‐4). The survey will address hardware and software features, data quality control, data format, sharing and analyses pipelines. The subgroups will develop early SRA drafts (M4-­‐5) that will be revised during a two-­‐day workshop (M6). The revised SRA drafts (M7) will be shared with international clinical and neuroimaging experts from academia, pharma, patients’ advocates, industry, regulatory agencies and scientific societies through an open web-­‐based social forum (M8). Contributions will be included in the final SRA across marker modalities (M9), which will be disseminated through websites of relevant EU scientific societies, international conferences and scientific papers.A drafts (M4-­‐5) that will be revised during a two-­‐day workshop (M6). The revised SRA drafts (M7) will be shared with international clinical and neuroimaging experts from academia, pharma, patients’ advocates, industry, regulatory agencies and scientific societies through an open web-­‐based social forum (M8). Contributions will be included in the final SRA across marker modalities (M9), which will be disseminated through websites of relevant EU scientific societies, international conferences and scientific papers.
Network JPco-fuND
Call Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration

Project partner

Number Name Role Country
1 University of Geneva Coordinator Italy
2 University of Trento Partner Italy
3 VU University Medical Center Partner Netherlands
4 University of Manchester Partner United Kingdom
5 VU University Medical Center Partner Netherlands
6 University Medical Center Hamburg-Eppendorf Partner Germany
7 University of Rome "La Sapienza" Partner Italy
8 Stavanger University Hospital Partner Norway
9 University Medical centre Ljubljana Partner Slovenia
10 CNRS, ICM Partner France
11 Janssen Research & Development, Johnson & Johnson Pharmaceutical Companies Partner
12 University Hospital of Cologne Partner Germany
13 Dokuz Eylul University Partner Turkey
14 Akershus University hospital / University of Oslo Partner Norway
15 Hopitaux Universitaires de Genève Partner Switzerland
16 University Pierre & Marie Curie/Hopital Pitié-Salpétrière Partner France
17 Charles University in Prague and Motol University Hospital Partner Czech Republic
18 Karolinska University Hospital - Karolinska Istitutet Partner Sweden
19 University of Oxford Partner United Kingdom
20 CATI - Neurospin Partner France
21 University of Lausanne - CHUV Partner Switzerland
22 Charles University in Prague and Motol University Hospital Partner Czech Republic
23 University of Genoa and IRCCS AOU San Martino-IST Partner Italy