Project: Dietary modulation of intestinal microbiota as trigger of liver health: role of bile acids

Acronym Di-Mi-Liv (Reference Number: JTC-2017-8)
Duration 01/04/2018 - 30/03/2021
Project Topic What: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. Alterations of intestinal microbiota composition and associated impairments of intestinal barrier function are critical in the onset and progression of NAFLD. Recent data suggest a pivotal role of bile acids and microbial bile acid metabolism as mediators of gut-liver-crosstalk subsequently affecting NAFLD initiation and progression. Soluble fibers like oat ß-glucans bind bile acids and modulate intestinal microbiota composition and may thereby affect metabolic parameters and liver health. Furthermore, intervention trails suggest that manipulating intestinal microbiota composition through prebiotics may improve disease progression of NAFLD. However, the molecular mechanisms involved remain incompletely understood and established therapeutic strategies are still missing. How: Di-Mi-Liv combines the complementary expertise of 5 groups with a strong background in various aspects of diet, liver disease, bile acids and intestinal microbiota. Through combining this expertise and combining clinical interventions with mouse models, the project aims to determine whether the interaction of bile acids and intestinal microbiota is critical for the initiating and progressing stages of NAFLD. Furthermore, it will be addressed whether this liver disease can be targeted through diet and more specifically with prebiotics, thereby improving disease progression and overall health. Who: The Di-Mi-Liv consortium consists of five funded partners and two collaborators, coordinated by Ina Bergheim, University of Vienna (Austria); email contact: The other funded consortium partners are Christian Trautwein (PI) and Kai Markus Schneider (Co-PI) , RWTH Aachen (Germany), Michael Trauner, Medical University of Vienna (Austria), Hanns-Ulrich Marschall, University of Gothenburg (Sweden) and Amélia Camarinha Silva, University of Hohenheim (Germany). The German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) and University Clinic RWTH Aachen, Center for Translational & Clinical Research Aachen (both Germany) are collaborating in this project.
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Call HDHL-INTIMIC Cofunded Call "Interrelation of the Intestinal Microbiome, Diet and Health"

Project partner

Number Name Role Country
1 University of Vienna Coordinator Austria
2 University Clinic RWTH Aachen Partner Germany
3 Medical University of Vienna Partner Austria
4 University of Gothenburg Partner Sweden
5 University of Hohenheim Partner Germany