Project: Transversal tissue engineering and nanomedicine approach towards an improved chronic wound therapy

Acronym NanoGSkin (Reference Number: EURONANOMED2017-147)
Duration 02/03/2018
Project Topic Current biological technologies for skin diseases aim to provide a matrix and antimicrobial support. However, due to existing limitation it is necessary to develop bioequivalent and cost-effective skin substitutes manufactured in a GMP facility in a relative short period of time. Granada Health Research Institute has developed a novel biomaterial based on nanostructured fibrin-agarose hydrogel that has proven to be effective for the tissue-engineered construction of artificial human corneas, oral mucosa, peripheral nerve regeneration and skin. Here we propose a multidisciplinary healthcare approach combining bioengineered skin, growth factor- and antibiotic-loaded nanoparticles (NPs) towards an improved chronic wound therapy. The NanoGrowSkin project will focus on the development of new advanced therapy tools/technologies in skin regeneration for the treatment of burns, by providing new alternative therapeutic options for many patients with chronic wounds. The first aim to be accomplished by NanoGrowSkin will be the optimization of human artificial skin models by using pharmaceutical quality products and the implementation of novel methods, such as nanomedicine technologies. This will allow the generation of biomaterials with improved and suitable biomechanical and antimicrobial properties for its therapeutic use in clinical approaches. In order to achieve this first goal, necessary histological, rheological and genetic quality controls are envisaged. The second aim of NanoGrowSkin will be to adapt the production of these new tools towards an optimal regulatory framework, including GMP regulation and EMA guidelines. Thirdly, NanoGrowSkin has foreseen a wider exploitation model. It will include the development of a market access approach in order to estimate the benefits of this treatment for the entire society.
Network EuroNanoMed III
Call Joint Transnational Call for Proposals (2017) for “European Innovative Research & Technological Development Projects in Nanomedicine”

Project partner

Number Name Role Country
1 Fundación para la Investigación Biosanitaria de Andalucía Oriental (FIBAO) - Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA) Coordinator Spain
2 OSI Health XXI Partner Spain
3 Istituto Biochimico Italiano Partner Italy
4 University of Bordeaux Partner France
5 Université de Technologie de Compiègne (UTC), France Partner France
6 National University of Ireland Partner Ireland