Project: CANCER MULTI-OMICS AVATARS FOR INTEGRATED PRECISION MEDICINE

Acronym	LANTERN (Reference Number: ERAPERMED2022-116)
Duration	01/04/2023 - 31/03/2026
Project Topic	Lung cancer is one of the most commonly diagnosed forms of cancer worldwide, accounting for approximately 12.2% of total cancer diagnoses. Despite the recent advances in treatment, prognosis still remains poor with a high mortality rate. The current therapeutic approaches have reached a significantly high level of complexity, due to the recent identification of mutations and other cancer heterogeneity drivers (i.e., actionable mutations or PD-L1 expression for immunotherapy indication), thereby complicating the process of decision-making by clinicians. The integration of "omics" datasets in different domains (i.e., genomics, proteomics) may further support clinicians in identifying innovative variables to support a new kind of comprehensive cancer care, towards personalized medicine. In the last decade, significant improvements have been observed in the development of omics technologies, resulting in an overwhelming number of variables to be considered while making decisions that can be hardly handled by a human operator. Interestingly, with the advent of advanced Artificial intelligence (AI) techniques, more information can be obtained via "Internet of Things" technologies and various omics datasets which could be used efficaciously in creating predictive models. These models can be used can be used either individually or merged in a multi-omics patient avatars to assist in the clinical decision-making process and introduce new paradigms of care and research, evaluating unexpected links among variables that were previously unexplored. Therefore, the primary aim of the LANTERN project is to develop accurate predictive models for lung cancer patients, using various omics-based variables and integrating well-established clinical factors with "big data" and advanced imaging features. With this, individual patient avatars can be created which will serve as powerful tools in guiding clinicians and researchers in making more accurate decisions.
Network	ERA PerMed
Call	5th Joint Transnational Call for Proposals (2022)

Project partner

Number	Name	Role	Country
1	Fondazione Policlinico Universitario “A. Gemelli” IRCCS	Coordinator	Italy
2	University of Debrecen	Partner	Hungary
3	Hospital de la Santa Creu i Sant Pau	Partner	Spain
4	Accademia del Paziente Esperto EUPATI - AdPEE	Partner	Italy
5	Technisce Universität Dresden	Partner	Germany
6	Koç University	Partner	Türkiye