Project: Genetic Carbohydrate Maldigestion as a model to study Food Hypersensitivity mechanism and guide personalised treatment using a non-invasive multiparametric test.

Acronym	GenMalCarb (Reference Number: JTC-2021_70)
Duration	02/04/2022 - 01/04/2025
Project Topic	It is estimated that about 20% of the population has a food intolerance and that in people with Irritable Bowel Syndrome which affects about 1 in 10 people in the UK, food intolerance is even higher. A new international research study involving scientists and patients from across the world, aims to investigate whether there is a genetic reason for this and what new therapies could be developed to treat the symptoms. Members of the GenMalCarb team have shown that, compared to healthy people, IBS patients more often carry defective (hypomorphic) SI gene variants. The SI gene produces an enzyme, called sucrase-isomaltase, which is used by the body to digest carbohydrates such as starch and table sugar (sucrose). These results suggest that a sub-group of IBS patients, if correctly identified, could benefit from personalised treatments using dietary interventions or enzyme supplementation. In order to develop specific treatments, researchers need to understand the exact mechanisms which lead to symptoms as a result of carbohydrate maldigestion. The GenMalCarb study, which is coordinated by experts from the University of Nottingham, will use a magnetic resonance imaging (MRI) platform that allows the analysis of gut responses to food in real time. The research team will use this platform to study carbohydrate maldigestion in IBS patients carrying hypomorphic SI variants. The study will be run in collaboration with international research teams. The GenMalCarb project aims to: - accurately establish how many IBS patients carry DNA changes predisposing to SI malfunction in an international study involving more than 30 centres worldwide (Work Package 1) - confirm SI dysfunction (reduced capacity to digest sucrose and starch) for all identified hypomorphic variants via experimental validation in cell-based models (Work Package 1) - Elucidate via MRI studies what part of the digestive process is dysfunctional in IBS patients carrying different SI variants, in response to ingestion of carbohydrate (Work Package 2) The results from this research will open up the possibility for new personalised therapies, based on tailor-made dietary treatments and enzyme supplementation.
Network	ERA-HDHL
Call	ERA-HDHL Joint Call 2021 FOOD_HYPERSENS

Project partner

Number	Name	Role	Country
1	University of Nottingham	Coordinator	United Kingdom
2	Christian-Albrechts University Kiel	Partner	Germany
3	University of Veterinary Medicine Hannover	Partner	Germany
4	Centro de Investigación Cooperativa en Biociencias CIC bioGUNE	Partner	Spain
5	Nestle Research	Observer	Switzerland