Project: Paternal RNA-mediated epigenetic inheritance of metabolic disorders: impact of weight loss on the human sperm epitranscriptome

Acronym	HEROS
Project Topic	Increasing evidence suggests that several non-communicable diseases, including obesity and its associated metabolic disorders, are inherited from parents to offspring over several generations by non-genetic mechanisms. HEROS aims to validate RNA-mediated epigenetic inheritance as a mechanism for obesity in humans. The major aim of the present study is to determine how the sperm epitranscriptome responds to environmental changes. Answering such a question might deliver valuable new insights into the molecular mechanism(s) involved in the process of the development of obesity and might also provide valuable new approaches to identify new obese-susceptibility.
Network	ERA-HDHL
Call	Call for Joint Action: Nutrition & the Epigenome

Project partner

Number	Name	Role	Country
1	C3M	Coordinator	France
2	Institut d'Investigació Biomèdica de Girona	Partner	Spain
3	JGU Mainz	Partner	Germany