Project: PREcision MEDicine in Coronary Artery Disease
| Acronym | PREMED-CAD (Reference Number: 7. JTC-2017_58) |
| Project Topic | Cardiovascular disease (CVD) represents the most important cause of morbidity and mortality in the EU, and causes an enormous socioeconomic impact with almost 200 Billion Euros annual costs. Despite the knowledge on CV risk factors and several biomarkers, current, existing tools fail to adequately identify subjects at short-term risk. Therefore, innovative approaches to enhance risk assessment and early identification of "at-risk subjects" are urgently needed. Within PREMED-CAD, we will take an interdisciplinary and translational approach integrating knowledge from CAD epidemiology, imaging, bioinformatics, statistics and molecular biology. PREMED-CAD builds on existing biomarker data of distinct CAD and subclinical myocardial ischemia phenotypes, functional imaging data, epidemiological cohort data and biobanks, bioinformatical methodologies and animal models. Existing blood-based and clinical biomarkers will be integrated in a biomarker signature. This signature will be validated in atherosclerosis-prone mouse models and human cohorts. The validated signature will be translated in an ongoing existing large preventive clinical trial comprising 3,000 patients with subclinical ischemia. PREMED-CAD will enable us to 1) pave the way for affordable tools for early recognition of individuals at immediate and short-term CAD risk, 2) identify the need for interventional strategies, 3) explore the molecular pathophysiology and signature of myocardial ischemia in a comprehensive view, and 4) apply precision medicine to affected individuals using an already financed clinical trial. |
| Network | ERA-CVD |
| Call | Joint Transnational Call for Proposals 2017: Mechanisms of early atherosclerosis and/or plaque instability in Coronary Artery Disease |
Project partner
| Number | Name | Role | Country |
|---|---|---|---|
| 1 | University Medical Centre Hamburg Eppendorf | Coordinator | Germany |
| 2 | IRCCS San Raffaele, Pisana | Partner | Italy |
| 3 | INSERM | Partner | France |