Project: Label-free PoC device based on 3D photonic Bottle microresonators for real-time high-Sensitive measurement of disease relevant biomolecules
| Acronym | PoC-BoSens (Reference Number: PS-2016_19) |
| Duration | 01/04/2018 - 31/03/2021 |
| Project Topic | The PoC-BoSens project consists of the realization and validation of an optofluidic-based Point-of-Care (PoC) system for early diagnosis of Lyme Borroliosis (LB) infected patients employing cell-based assays. The diagnostic readout in these assays is the quantitative determination of released cytokine biomarkers in a fast (15 minutes), reliable and labelfree sensing microsystem. This approach will allow a fast and early detection of a LB infection, thereby enabling the fast treatment and eliminating side effects and associated costs. Thus, this novel analysis platform will contribute to the improvement of citizens’ health status and to the sustainability of health care systems, as well as stimulate the innovation and market-status of European small and medium enterprises (SMEs). The technology behind the PoC sensing microsystem will be defined by the combination of an array of photonic transducing elements based on novel three-dimensional bottle microresonators (3DBMRs) and a microfluidic system for transportation of test samples on the transducing elements. The BMR is a class of resonant structures with high sensitivity, a high grade of compactness, and multiplexing capabilities. The complete integration on a chip of a BMR array will allow the development of sensitive (pg/ml level), fast, portable and low-cost photonic platform for PoC testing which might easily be used by untrained personnel, and has the potential for implementation in field medical Units and crisis centres. PoC-BoSens will provide the technological innovation to industrial and clinical sectors with a chip production cost of around 16.5 € and a portable readout system with an approximate production cost of around 6,000 €. A strong translational cooperation of academic and SME partners with expertise in the field of photonic sensors, bioengineering, microfluidic systems, photonic&electronic packaging, data processing, biomedicine and in vitro diagnostics is reflected in PoC-BoSens. |
| Network | PhotonicSensing |
| Call | Photonics based sensing |
Project partner
| Number | Name | Role | Country |
|---|---|---|---|
| 1 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung E.V | Coordinator | Germany |
| 2 | MDX Devices GmbH | Partner | Germany |
| 3 | IfU Diagnostic Systems GmbH | Partner | Germany |
| 4 | AIT Austrian Institute of Technology GmbH | Partner | Austria |
| 5 | Scuola Superiore SantAnna | Partner | Italy |
| 6 | Unitive Design and Analysis Ltd | Partner | United Kingdom |
| 7 | SYEL srl | Partner | Italy |
| 8 | DIARECT AG | Partner | Germany |
| 9 | Scienion AG | Partner | Germany |