Project: Unlocking and Re-establishing Effective mechanisms of the Wiring between brain and lower limb to Improve REcovery of walkING after stroke

Acronym REWIRING (Reference Number: JTC2024 - Brain-Body_REWIRING_1)
Project Topic There is an urgent need for innovative treatments to enhance the recovery of lower limb motor function after stroke as the regaining of ambulatory ability is crucial for independence. In this regard, Brain Computer Interfaces (BCIs) have a unique position as they enable a direct re-connection between the brain and body, holding great potential to improve motor function recovery after stroke. However, current BCI solutions hardly manage to address the complexity and inter-subject variability that characterizes motor function loss and regaining after stroke. The ambition of the REWIRING project is to deploy a beyond state of art, comprehensive BCI system, the Brain-Body Computer Interface (B-BCI), able to reestablish a functional connection between the brain and the periphery to eventually improve recovery of walking after stroke (B-BCI control module). The novelty of the proposed system lays in the re-connection that will be operated according to internal neural models of (residual) motor skills grounded on the understanding of reciprocal influence between action and perception. As such, these models will be generated thanks to a multimodal monitoring of individual motor performance parameters that are operated by the B-BCI under different locomotor-related movement conditions (B-BCI monitoring module). The B-BCI will ultimately enable for an unprecedented, authentically personalized, evidence-based BCI-based reconnection between the brain and periphery.
Network NEURON Cofund2
Call Neuron Cofund2 Joint Call 2024

Project partner