Project: Principles of choroid plexus-mediated brain-body interactions in the context of systemic and peripheral pathologies
| Acronym | ChorNEXUS (Reference Number: JTC2024 - Brain-Body_ChorNEXUS_1) |
| Project Topic | The choroid plexus (CP) provides an interface between the blood and the brain. It functions as the blood-cerebrospinal fluid (CSF) barrier, the CSF secretory organ, and a site for immune surveillance. Thereby, the CP is perfectly positioned for regulating brain-body interaction. Yet, how the CP senses and responds to this flow of information in health and disease is poorly understood. It is also unclear whether the CP can be targeted for clinical interventions of brain diseases. The objective of ChorNEXUS is to identify the principles of CP-mediated brain-body interactions in systemic and peripheral pathologies in view to identify biomarkers and targets for clinical interventions. ChorNEXUS will combine research in preclinical models (mouse, rat and zebrafish) and humans to identify: (1) the impact of peripheral injuries on the CP and the brain, (2) how CP alterations lead to maladaptive brain plasticity and contribute to disease, (3) markers of CP dysfunction for diagnostic purpose, (4) CP interventions for treatment of brain disorders. We will investigate the CP from the angle of both inflammatory and not inflammatory pathologies. By combining preclinical expertise in CP, CSF, and neuronal physiology with the clinical management of patient cohorts with peripheral injury diseases, ChorNEXUS is well positioned to identify the overarching principles of CP-mediated brain regulation in health and disease. This will be instrumental for future development of therapies. |
| Network | NEURON Cofund2 |
| Call | Neuron Cofund2 Joint Call 2024 |