Project: Spinal cord repair: releasing the neuron-intrinsic brake on axon regeneration
| Acronym | AxonRepair |
| Duration | 01/01/2017 - 01/01/2020 |
| Project Topic | Problem: Spinal cord injury (SCI) leads to permanent disability and is a significant clinical problem with 130.000 new cases/year worldwide. Following SCI long axon tracts fail to regenerate. This is the primary reason for the sustained loss of bodily functions. Aim: AxonRepair aims to develop a strategy to promote long-distance axon regeneration in the injured spinal cord by reprogramming neurons into a regenerative state and by overcoming the axon transport block that is a barrier to axon regeneration. In AxonRepair we brought together world-class experts on transcriptional control of axon regeneration, axon transport and therapeutic gene delivery. Workplan: Work package (WP) 1 aims to reprogram neurons into a regenerative state by testing the effect of gene therapeutic combinatorial delivery of key transcription factors identified in our collective’s discovery pipeline. WP 2 aims to restore axonal transport of growth-related axonal receptors. WP 3 provides novel mechanistic insight into how interventions at the transcriptional and the axon transport level work and whether these interventions act synergistically on axon regeneration. Exploitation of results: At completion of the project we expect to have developed a method to release the brake on axon regeneration. The participation of the gene therapy company UniQure ensures that newly generated know-how will be exploited rapidly by entering in a co-development agreement and/or intellectual property strategy. |
| Network | NEURON Cofund |
| Call | Call for Proposals for "European Research Projects on External Insults to the Nervous System" |
Project partner
| Number | Name | Role | Country |
|---|---|---|---|
| 1 | Netherlands Institute for Neuroscience | Coordinator | Netherlands |
| 2 | University of Cambridge | Partner | United Kingdom |
| 3 | King's College London | Partner | United Kingdom |
| 4 | German Center for Neurodegenerative disease | Partner | Germany |
| 5 | McGill University | Partner | Canada |
| 6 | Slovak Academy of Sciences | Partner | Slovakia |