Project: Developing and validating blood and imaging BIOmarkers of AXonal injury following Traumatic Brain Injury

Acronym BIO-AX-TBI
Duration 01/04/2017 - 31/03/2020
Project Topic AIM: We will investigate the relationship between blood, microdialysis and neuroimaging markers of axonal injury after traumatic brain injury (TBI). New methods provide 100-1000 fold increases in sensitivity. We exploit this advance to investigate neurofilament light (NFL) and tau proteins, as well as other plasma markers, with advanced magnetic resonance imaging (MRI) measures of axonal injury. WORK PLAN: We will perform a multicenter study of adult TBI closely aligned with the InTBIR collaborative effort and linked to the large CREACTIVE TBI study. Work Package (WP) 1 will study these factors in a large cohort of moderate/severe TBI patients. WP 2 will investigate the longitudinal relationship between neuroimaging and plasma biomarkers. WP 3 will combine microdialysis, neuroimaging and plasma sampling of axonal proteins to provide a mechanistic understanding of axonal injury progression and validate the axonal origin of the plasma biomarkers. WP 4 will validate findings from the study in an additional 1000 patients from CREACTIVE. EXPLOITATION OF RESULTS: The results will guide the incorporation of plasma biomarkers and advanced MRI measures of axonal injury into medical practice. Our aim is provide robust evidence about the best measures for the early assessment of axonal injury. By validating neuroimaging and plasma biomarkers for axonal injury we will facilitate prognostication after TBI, as well provide tools to inform the selection and evaluation of treatment.
Network NEURON Cofund
Call Call for Proposals for "European Research Projects on External Insults to the Nervous System"

Project partner

Number Name Role Country
1 Imperial College London Coordinator United Kingdom
2 University College London (UCL) Partner United Kingdom
3 University of Lausanne, Switzerland Partner Switzerland
4 Mario Negri Institute for Pharmacological Research Partner Italy