Understanding the mechanisms of non-pharmacological interventions

Basic Information

Neurodegenerative diseases are debilitating and largely untreatable conditions that are strongly linked with age. Worldwide, there are estimated to be 50 million people with Alzheimer’s disease and related disorders, the most common group of neurodegenerative diseases. This figure is expected to double every 20 years as the population ages. The total direct and informal care costs of Alzheimer’s, Parkinson’s and related disorders are expected to surpass €350 billion per year across the European Union. Existing treatments for neurodegenerative diseases are limited in effect and mainly address the symptoms rather than the cause or the progressive course. In this context, the EU Joint Programme - Neurodegenerative Disease Research (JPND) has been established to better coordinate research efforts across countries and disciplines to more rapidly find causes, develop cures and identify better ways to care for people with neurodegenerative diseases.

Network JPND
Website https://www.neurodegenerationresearch.eu/initiatives/annual-calls-for-proposals/closed-calls/understanding-the-mechanisms-of-non-pharmacological-interventions/
Aim of the joint call The aim of the call is to establish a number of ambitious, innovative, multi-disciplinary and multi-national collaborative research projects that aim at understanding the biomedical, psychological and/or social mechanisms of non-pharmaceutical interventions in order to identify potential target sites for enhanced personalized interventions or a combination of pharmacological and non-pharmacological interventions. Proposals must focus on one or several of the following neurodegenerative diseases: • Alzheimer’s disease and other dementias • Parkinson’s disease and PD‐related disorders • Prion diseases • Motor neuron diseases • Huntington’s disease • Spinocerebellar ataxia (SCA) • Spinal muscular atrophy (SMA)
Type of joint call Two Stages - Call with pre-proposals and full proposals submissions
Launch date 04/01/2022
Deadline Pre-Proposal 01/03/2022 Submitted proposal: 94
Deadline Full-Proposal 28/06/2022 Submitted proposal: 39
Evaluation End Date 09/09/2022 Successful proposal: 27 Proposals funded: 14
Is call co-funded? No
Call follow up funding n/a
Call reasons n/a
Research fields
  • Health
Type of research n/a
Target groups n/a
Participating networks n/a

Organisations Participating

Country Organisation
Australia National Health and Medical Research Council (NHMRC)
Belgium National Fund for Scientific Research (FNRS)
Belgium Research Foundation Flanders (FWO)
Canada Canadian Institutes of Health Research (CIHR)
Czech Republic Ministry of Education Youth and Sports (MEYS-MSMT)
Denmark Innovation Fund Denmark (Innofond)
Finland Academy of Finland (AKA)
France National Research Agency (ANR)
Germany Federal Ministry of Education and Research (BMBF)
Hungary National Research, Development and Innovation Office (NKFIH)
Israel Ministry of Health (CSO-MOH)
Italy Ministry of Health (MOH/MDS)
Latvia Latvian Council of Science (LCS)
Latvia State Education Development Agency (VIAA)
Luxembourg National Fund for Research (FNR)
Netherlands The Netherlands Organisation for Health Research and Development (ZonMw)
Norway Research Council of Norway (RCN)
Poland National Science Centre (NCN)
Portugal Foundation for Science and Technology (FCT)
Slovakia Ministry of Education, Science, Research and Sport of the Slovak Republic (MINEDU)
Spain Institute of Health Carlos III (ISCIII)
Switzerland Swiss National Science Foundation (SNSF/SNF)
Turkey The Scientific and Technological Research Council of Turkey (TUBITAK)

Funded Projects

Acronym Title Start End No. partners
AD_Imprint Unlock the early life pathological imprinting of Alzheimer's... 5
AUTOFUS Facilitating focused ultrasound-mediated Tau clearance in Al... 5
DC4MND Multidimensional mechanistic investigations of trans spinal ... 6
EPI-3E Defining (sex and age) cell-specific epigenetic mechanisms u... 7
EXERBRAIN Crosstalk between exercise and brain lipid metabolism in the... 3
Good Vibes Preventing Alzheimer's disease conversion by monitored vibra... 5
HiCALS Hypothalamic mechanisms of High-Calorie intervention in ALS 5
Multi-MeMo Shorter- and longer-term mechanisms of multimodal interventi... 6
NEURODIET Molecular Mechanisms of Dietary Intervention on Neurodegener... 5
REBALANCE Mechanisms of focused ultRasound mEdiated BrAin cLeAniNg Cou... 6
RECAST Rebalancing sleep-wake disturbances in Parkinson's Disease w... 6
StepuP Steps against the burden of Parkinson’s Disease 6
TREMENDOS The role of microglia in the effects of environmental enrich... 5
UNITE-PD Unraveling the Neural mechanisms underlying compensation str... 4