Project: KlebNet: a One Health network bridging science and surveillance on antimicrobial resistant Klebsiella

Acronym KlebNet (Reference Number: JPIAMR_2018_N014)
Duration 30/04/2019 - 31/12/2020
Project Topic Klebsiella, particularly Klebsiella pneumoniae (hereafter, collectively called Kp) is an opportunistic pathogen of humans and animals that now tops the ‘urgent threat’ lists of CDC, ECDC and WHO due to high rates of multidrug resistance. Kp can also play a pioneer role in the amplification of novel AMR mechanisms acquired from environmental microbes, which can then spread to other important bacterial pathogens, as exemplified with KPC-2 or NDM-1 carbapenemases. Despite this, Kp does not currently feature as a target of surveillance efforts. Although Kp is generally viewed as ‘ubiquitous’, data on its distribution in healthy people, the environment, animals and the food chain are scarce, and the transmission of Kp and its AMR gene cargo between these potential sectors and hospitalised individuals is poorly understood. The KlebNet network is dedicated to identifying key knowledge gaps relating to Kp ecology and transmission, and to developing a One Health strategy for Kp surveillance. Strategy: Research on ecological distribution of Kp and on its transmission routes should, to be actionable, be guided by expected impact on implementation into surveillance and control programs. An optimal Kp surveillance strategy must be defined based on (1) Most advanced knowledge on the ecology, population biology and epidemiology of the pathogen, combined with (2) Actionability and practical aspects of the implementation of surveillance, in high-income as well as in low- and medium income countries (LMIC), and across sectors (clinical, animal, food). Objectives: (1) To review current knowledge on Kp reservoirs, population biology and transmission dynamics, and to identify and prioritise gaps where further research is required; and (2) To issue recommendations on how Kp surveillance should be implemented and harmonised across environment, animals, food and hospitals, including both technical and strategic considerations.
Website visit project website
Network JPI AMR
Call 7th Joint Call of JPIAMR

Project partner

Number Name Role Country
1 Pasteur Institute Coordinator France
2 University of Bath Observer United Kingdom
3 University of Freiberg Observer Germany
4 Stavanger University Hospital Observer Norway
5 University of Melbourne Observer Australia
6 The Wellcome Trust Sanger Institute Observer United Kingdom
7 Technical University of Denmark Observer Denmark
8 University of Birmingham Observer United Kingdom
9 Karolinska Institutet Observer Sweden
10 University of Paris 11 Medical School Observer France
11 Public Health England Observer United Kingdom
12 University of Bristol Observer United Kingdom
13 The Wellcome Trust Observer Viet Nam
14 Pasteur Institute Observer Madagascar
15 University of São Paulo Observer Brazil
16 KEMRI Observer Kenya
17 National Agency for Food, Environmental and Occupational Health & Safety Observer France
18 Istituto Zooprofilattico Sperimentale Observer Italy
19 Pasteur Institute Observer France
20 Statens Serum Institute Observer Denmark
21 National University of Ireland Galway Observer Ireland
22 Université de Bourgogne Dijon Observer France
23 University of Pavia Observer Italy
24 National Medicines Institute Observer Poland
25 The James Hutton Institute Observer United Kingdom
26 University of Glasgow Observer United Kingdom
27 University Medical Center Utrecht Observer Netherlands
28 Versailles Saint Quentin University Observer France
29 Pasteur Institute Observer France
30 The Arctic University of Norway Observer Norway
31 The Arctic University of Norway Observer Norway