Project: Intensive Care Airway and Lung Microbiome Network ICALM Network

Acronym	ICALM (Reference Number: JPIAMR_2018_N020)
Duration	01/01/2019 - 31/12/2019
Project Topic	Hospital acquired pneumonia (HAP) is the most frequent infection acquired in the Intensive Care Unit (ICU). ICU-related respiratory infections arise as a consequence of the processes of ICU care. Mechanical ventilation (MV) is potentially lifesaving, but also carries microorganisms into the lower airways, changing the native flora, and increasing the risk of Ventilator-Associated Tracheobronchitis (VAT) and Ventilator-Associated Pneumonia (VAP). Data concerning the characteristics of respiratory microbiota and its alterations in illness are largely limited to the respiratory microbial flora of patients with cystic fibrosis, and little is known about airway microbiota alterations in critical illness. We published the most comprehensive study on this topic, and found that mechanical ventilation, but not antibiotic administration, was associated with changes in the respiratory microbiome. With funding from JPIAMR, we will empower a multinational team to develop common surveillance methods and monitoring approaches to build a global study of the lung microbiome in critical illness, and its associations with modifiable environmental colonisation and pneumonia in the individual patient.
Website	visit project website
Network	JPI AMR
Call	7th Joint Call of JPIAMR

Project partner

Number	Name	Role	Country
1	Trinity College	Coordinator	Ireland
2	D‘Or Institute for Research in Education	Observer	Brazil
3	University of Toronto	Observer	Canada
4	Hospital Clinic and Universidad Barcelona	Observer	Spain
5	Friedrich-Schiller-University	Observer	Germany
6	Catholic University of Rome	Observer	Italy
7	Saint-Louis Teaching Hospital	Observer	France
8	University of Amsterdam	Observer	Netherlands
9	Erasme Univ Hospital	Observer	Belgium
10	University of Linköping	Observer	Sweden
11	University of British Columbia	Observer	Canada
12	University of Toronto	Observer	Canada
13	University of Michigan Medical School	Observer	United States
14	Royal Brisbane and Womens’ Hospital	Observer	Australia
15	University of Toronto	Observer	Canada
16	Prince of Wales Hospital	Observer	China
17	King Saud Bin Abdulaziz University	Observer	Saudi Arabia