Project: Intensive Care Airway and Lung Microbiome Network ICALM Network

Acronym ICALM (Reference Number: JPIAMR_2018_N020)
Duration 01/01/2019 - 31/12/2019
Project Topic Hospital acquired pneumonia (HAP) is the most frequent infection acquired in the Intensive Care Unit (ICU). ICU-related respiratory infections arise as a consequence of the processes of ICU care. Mechanical ventilation (MV) is potentially lifesaving, but also carries microorganisms into the lower airways, changing the native flora, and increasing the risk of Ventilator-Associated Tracheobronchitis (VAT) and Ventilator-Associated Pneumonia (VAP). Data concerning the characteristics of respiratory microbiota and its alterations in illness are largely limited to the respiratory microbial flora of patients with cystic fibrosis, and little is known about airway microbiota alterations in critical illness. We published the most comprehensive study on this topic, and found that mechanical ventilation, but not antibiotic administration, was associated with changes in the respiratory microbiome. With funding from JPIAMR, we will empower a multinational team to develop common surveillance methods and monitoring approaches to build a global study of the lung microbiome in critical illness, and its associations with modifiable environmental colonisation and pneumonia in the individual patient.
Website visit project website
Network JPI AMR
Call 7th Joint Call of JPIAMR

Project partner

Number Name Role Country
1 Trinity College Coordinator Ireland
2 D‘Or Institute for Research in Education Observer Brazil
3 University of Toronto Observer Canada
4 Hospital Clinic and Universidad Barcelona Observer Spain
5 Friedrich-Schiller-University Observer Germany
6 Catholic University of Rome Observer Italy
7 Saint-Louis Teaching Hospital Observer France
8 University of Amsterdam Observer Netherlands
9 Erasme Univ Hospital Observer Belgium
10 University of Linköping Observer Sweden
11 University of British Columbia Observer Canada
12 University of Toronto Observer Canada
13 University of Michigan Medical School Observer United States
14 Royal Brisbane and Womens’ Hospital Observer Australia
15 University of Toronto Observer Canada
16 Prince of Wales Hospital Observer China
17 King Saud Bin Abdulaziz University Observer Saudi Arabia