Project: Impact of reducing colistin use on colistin resistance in humans and poultry in Indonesia

Acronym COINCIDE (Reference Number: JPIAMR_2021_P008)
Duration 01/06/2022 - 31/05/2025
Project Topic Colistin (polymyxin E) is considered a last resort antimicrobial for treatment of infections with multidrug- resistant bacteria, classified by WHO as ‘highest prioritized, critically important for human medicine’. WHO suggests to ban or highly restrict its use in animals. In Indonesia, colistin resistance in human Escherichia coli isolates is poorly characterized as it requires specific non-routine tests. Presence of colistin resistance in E. coli in poultry resulted in a ban for livestock in Indonesia in 2020. However, colistin is still suspected to be routinely used in humans in multiple settings but the reasons for these practices are poorly understood. The ban on colistin use in livestock offers a unique opportunity to assess the impact of this intervention on colistin resistance in humans and animals, and how a One Health perspective can strengthen this intervention. This project aims to: i) determine phenotypic and genotypic colistin resistance in E. coli from humans and poultry in Indonesia; ii) assess the impact of the colistin ban on resistance in E. coli in animals and humans; iii) estimate the transmission of colistin resistance between animals and humans; iv) study colistin use and perceptions at the community level; and v) expand the initial colistin ban in the animal production sector into an integrative multi-sectorial One Health intervention, which will be designed and implemented using a community participatory approach. This project will provide a strong scientific basis to AMR policies in Indonesia, with great significance across Southeast Asia
Website visit project website
Call 1st JPIAMR-ACTION Joint Call 2021

Project partner

Number Name Role Country
1 Faculty of Medicine, Universitas Indonesia Coordinator Indonesia
2 Erasmus MC University Medical Center Rotterdam Partner Netherlands
3 Utrecht University, Faculty of Veterinary Medicine Partner Netherlands
4 Center for Indonesian Veterinary Analytical Studies Partner Indonesia
5 University of Calgary Partner Canada
6 Institute of Tropical Medicine Partner Belgium
7 Directorate of Veterinary Public Health, DG of Livestock and Animal Health Services, MoA-Indonesia Observer Indonesia