Project: Standardization of diagnostics and antimicrobial susceptibility testing and clinical interpretation in animal mycoplasmas.

Acronym MyMIC (Reference Number: JPIAMR_NC_2022-019)
Project Topic Animal mycoplasmas are major pathogens causing various diseases in livestock and pets, with significant economic losses for farmers. Their control relies largely on antimicrobial (ATB) use. Inappropriate and sustained use of ATB can select for resistance in the targeted bacteria, hence hampering treatment efficacy, but non-target microorganisms are also affected, including zoonotic/food-borne bacteria with significant impact on human health. The efficacy of ATBs in vivo can be indirectly assessed by in vitro susceptibility testing. However, existing standard procedures for AST could not be used for mycoplasmas, because of their different culture requirements and growth. The lack of standardized consensus procedures and quality control strains makes comparisons between studies difficult or impossible. Moreover, there are no clinical breakpoints or epidemiological cut-off (ECOFF) values determined specifically for animal mycoplasmas, which complicates the interpretation of results. The objective of this project is to set up a network of laboratories working on mycoplasma diagnostics and their susceptibility to ATBs to compare the different methods used and the results of minimum inhibitory concentrations (MIC). This project will lead to the drafting of guidelines for a standardized culturing, identification and determination of MICs. Moreover, the aggregation of MIC data obtained by the different laboratories will determine the first tentative ECOFFs for some Mycoplasma species to help clinical interpretation of MICs, and guide veterinarians toward a reasonable use of ATBs.
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Network JPIAMR-ACTION
Call 3rd JPIAMR-ACTION Joint Call 2022

Project partner

Number Name Role Country
1 French Agency for Food, Environmental and Occupational Health and Safety Coordinator France
2 French Agency for Food, Environmental and Occupational Health and Safety Observer France
3 French Agency for Food, Environmental and Occupational Health and Safety Observer France
4 Royal GD Observer Netherlands
5 Royal GD Observer Netherlands
6 Clinic for Birds, Reptilies, Amphibians and Fish Observer Germany
7 Veterinary Medical Research Institute Observer Hungary
8 Universidad de Las Palmas de Gran Canaria Observer Spain
9 Universidad de Las Palmas de Gran Canaria Observer Spain
10 Universidad de Las Palmas de Gran Canaria Observer Spain
11 Ghent University Observer Belgium
12 Istituto Zooprofilattico Sperimentale delle Venezie Observer Italy
13 Istituto Zooprofilattico Sperimentale delle Venezie Observer Italy
14 Istituto Zooprofilattico Sperimentale delle Venezie Observer Italy
15 Animal and Plant Health Agency (Govt) Observer United Kingdom
16 Kimron veterinary Institute Observer Israel
17 Finnish Food Authority Observer Finland
18 Finnish Food Authority Observer Finland
19 University of Bern Observer Switzerland
20 University of Bern Observer Switzerland
21 National Veterinary Institute Observer Sweden
22 National Veterinary Institute Observer Sweden
23 National Veterinary Institute Observer Sweden
24 Asia-Pacific Centre for Animal Health Observer Australia
25 Asia-Pacific Centre for Animal Health Observer Australia
26 Asia-Pacific Centre for Animal Health Observer Australia
27 Asia-Pacific Centre for Animal Health Observer Australia
28 Asia-Pacific Centre for Animal Health Observer Australia
29 National Veterinary Research Institute Pulawy Observer Poland
30 Asia-Pacific Centre for Animal Health Observer Australia
31 Asia-Pacific Centre for Animal Health Observer Australia
32 Asia-Pacific Centre for Animal Health Observer Australia
33 Asia-Pacific Centre for Animal Health Observer Australia
34 National Veterinary Research Institute Observer Poland
35 University of Maiduguri Observer Niger
36 University of Liverpool Observer United Kingdom
37 Veterinary Medical Research Institute Observer Hungary
38 Veterinary Medical Research Institute Observer Hungary
39 Veterinary Medical Research Institute Observer Hungary
40 VetAgro Sup Observer France
41 University of Agriculture Peshawar Observer Pakistan
42 University of Agriculture Peshawar Observer Pakistan
43 University of Veterinary Medicine, Vienna Observer Austria
44 Centro National de Sanidad Agropecuaria Observer Cuba
45 University of Ghent Observer Belgium
46 Centre de Coopération International en Recherche Agronomique pour le Développement Observer France
47 Centre de Coopération International en Recherche Agronomique pour le Développement Observer France
48 Centre de Coopération International en Recherche Agronomique pour le Développement Observer France