Project: Harmonized Hippocampal Subfield Segmentation Working Group

Acronym HSG (Reference Number: JPCOFUND_FP-940-006)
Duration 01/10/2016 - 31/03/2017
Project Topic Hippocampal subfield segmentation is a central focus for studies of neurodegeneration. Improved specificity of subfield volume may be used as sensitive diagnostic criteria to determine pathology as the subfields show differential vulnerability in aging and disease. Convergence of evidence across studies is hampered by substantial disagreement among extant segmentation protocols. To resolve this major barrier, HSG will develop a valid, reliable, and harmonized protocol for in vivo hippocampal subfield segmentation that can be adopted as the gold standard for neurodegenerative research. Due to the complexity of the structure, the HSG determined a multistage method that will 1st develop a protocol for the hippocampal body (the largest, mid-section of the hippocampus) using high-resolution T2-weighted 3 Tesla MRI scans before developing the protocol in the remainder of the hippocampus. Neuroanatomists (Amunts, Augustinack, Insausti) contributed 3 different labeled ex vivo datasets, serving as additional reference atlases of subfield boundary definition, while accounting for interindividual and across-lab variability. Next, the HSG will 1) determine whether the Harmonized Hippocampal Protocol (HarP; developed for whole structure volumetry) can be applied to high-resolution T2-weighted scans as the outer boundary, and 2) propose and test boundaries between adjacent subfields based upon reference atlases, the advice of the consulting neuroanatomists, and the expertise of the HSG in vivo MRI imaging members. Delphi procedure will be used to solicit feedback and establish consensus among the larger HSG community (~150 participants from > 15 countries), following which six expert raters will perform a formal reliability analysis. Finally, the protocol will be disseminated through conference presentations and a published manuscript. Following the completion of the hippocampal body protocol, the working group will apply the same methods to the development, reliability testing, and dissemination of a subfield segmentation protocol for the hippocampal head and tail (the anterior and posterior part of the hippocampus).
Network JPco-fuND
Call Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration

Project partner

Number Name Role Country
1 Baycrest Health Sciences Coordinator Canada
2 McGill University Partner Canada
3 Harvard University Partner United States of America
4 Heinrich-Heine University Düsseldorf Partner Germany
5 Max Planck Institute for Human Development Partner Germany
6 Otto-von-Guericke University Partner Germany
7 San Jose State University Partner United States of America
8 University of California, Davis Partner United States of America
9 Hôpital de la Pitié-Salpêtrière Partner France
10 Univ. IL Urbana-Champaign Partner United States of America
11 Université de Caen Partner France
12 Université de Caen Partner France
13 Universidad de Castilla-La Mancha Partner Spain
14 Stanford University Partner United States of America
15 University of California, San Francisco Partner United States of America
16 McGill University Partner United States of America
17 Wayne State University Partner United States of America
18 University of California, Irvine Partner United States of America
19 University of California, Irvine Partner United States of America
20 University of Alberta Partner Canada
21 Université de Caen & University of California, San Francisco Partner France
22 Northwestern University Partner United States of America
23 University of Pennsylvania Partner United States of America
24 University of Alberta Partner Canada