Project: Harmonising Brain Imaging Methods for Vascular Contributions to Neurodegeneration

Acronym HARNESS (Reference Number: JPCOFUND_FP-940-013)
Duration 01/10/2016 - 31/03/2017
Project Topic Vascular disease is the second most common cause of dementia. Neuroimaging research has identified many manifestations of cerebrovascular disease, with complex effects on brain structure and function. A previous JPND-funded initiative provided highly cited Standards for Reporting Vascular Changes on Neuroimaging (STRIVE), unifying the field around common lesion definitions and terminology. The time is now ripe to build on this consensus by disseminating harmonised acquisition protocols, providing access to exemplar MR datasets for reader reliability training and quantitative computerized algorithm development, and recommending methods in emerging areas of research. Following a series of teleconferences and an in-person workshop, our group will: 1) collect MR protocols and make them publicly available via a website; 2) collect exemplar MR data demonstrating a range of cerebrovascular lesion types, and develop a framework for a password-protected web-based image repository to make these data made freely available to the research community; 3) provide recommendations for reliability and reproducibility testing for multi-centre studies; and 4) provide recommendations for acquisition protocols in emerging research areas in cerebral small vessel disease (including 7T imaging, diffusion tensor imaging, perfusion and vascular reactivity, perivascular spaces and PET molecular imaging).
Network JPco-fuND
Call Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration

Project partner

Number Name Role Country
1 University of Calgary Coordinator Canada
2 University of Calgary Partner Canada
3 University of Calgary Partner Canada
4 University of Edinburgh Partner United Kingdom
5 University of Toronto Partner Canada
6 Leids Universitair Medisch Centrum Partner Netherlands
7 University of Bordeaux Partner France
8 Laval University Partner France
9 Imperial College London Partner United Kingdom
10 Erasmus MC Partner Netherlands
11 Deutsches Zentrum fur Neurodegenerative Erkrankungen e.V. (DZNE) Partner Germany
12 Erasmus MC Partner Netherlands
13 University of New South Wales Partner Australia
14 University Medical Center Utrecht Partner Netherlands
15 Lariboisière Hospital Partner France
16 McGill University Partner Canada
17 University of California at Davis Partner United States of America
18 Ludwig-Maximilians-University Munich Partner Germany
19 Medical University Graz Partner Austria
20 Massachusetts General Hospital Partner United States of America
21 University Hospital Carl Gustav Carus Partner Germany
22 The Chinese University of Hong Kong Partner
23 University of Florence Partner Italy
24 University of New South Wales Partner Australia
25 Boston University Partner United States of America
26 Maastricht University Medical Centre Partner Netherlands
27 Maastricht University Medical Centre Partner Netherlands
28 Massachusetts General Hospital Partner United States of America
29 Deutsches Zentrum fur Neurodegenerative Erkrankungen e.V. (DZNE) Partner Germany
30 Lariboisière Hospital Partner France
31 Radboud University Nijmegen Medical Center Partner Netherlands
32 Ludwig-Maximilians-University Munich Partner Germany
33 University of Toronto Partner Canada
34 Aarhus University Partner Denmark
35 University of Leeds Partner United Kingdom
36 University of Edinburgh Partner United Kingdom
37 Erasmus MC Partner Netherlands
38 University of Bordeaux Partner France
39 Icealandic Heart Association Partner Iceland
40 National Institutes of Health Partner United States of America
41 University of Bordeaux Partner France
42 Boston University Medical Centre Partner United States of America
43 University of Bordeaux Partner France
44 Massachusetts General Hospital Partner United States of America
45 University of Western Ontario Partner Canada
46 University College London Partner United Kingdom