Project: Harmonisation metabolic FDG brain pattern characteristics

Acronym PETMETPAT (Reference Number: JPCOFUND_FP-940-010)
Duration 01/10/2016 - 31/03/2017
Project Topic Multivariate analysis (principal component analysis) of cerebral glucose consumption (FDG-PET) provides characteristic abnormal disease patterns for neurodegenerative degeneration (ND) like in PD and AD. The expression of such a pattern can be quantified in each subject allowing to study disease development. This is very useful for clinical practice and various research efforts. At the UMCG Groningen and UMCL Lubljana this multivariate analysis has been established and validated and is available for any other center throughout Europe. FDG-PET images can be uploaded anonymously locally and processed centrally. The interest in this method is growing markedly, but the implementation of this method and its local validation forms a big obstacle for each regional center in Europe. One issue that limits the accuracy of the multivariate analysis, is the non-uniform data acquisition and image reconstruction at the various PET/CT and PET/MR sites in Europe.. This harmonisation workgroup aims to determine the standards of data acquisition and reconstruction such that they can be transformed in guidelines for all European centres. A positive example is the similar work concerning the European oncology FDG PET/CT guidelines. The results of our workgroup is expected to make diagnosis of ND easier, reliable and more reproducible throughout Europe.
Network JPco-fuND
Call Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration

Project partner

Number Name Role Country
1 University Medical Center Groningen Coordinator Netherlands
2 University Medical Center Groningen Partner Netherlands
3 University Medical Center Ljubljana Partner Slovenia
4 Philipps-University of Marburg, Germany Partner Germany
5 Centre for Integrative Neuroscience A.C. (CINAC) Partner Spain
6 Centre Hospitalier Régional de Namur (CHRN) Partner Belgium
7 Academic Medical Center University of Amsterdam Partner Netherlands
8 Turku PET Centre Partner Finland