Project: Full exploitation of High-Dimensionality in brain imaging

Acronym Full-HD (Reference Number: JPCOFUND_FP-940-020)
Duration 01/10/2016 - 31/03/2017
Project Topic High-throughput technology can now provide rich information on a person's biological makeup and environmental surroundings. Important discoveries have been made by relating these data to various health outcomes in fields such as genomics, proteomics, and medical imaging. Cross-investigations between several high-throughput technologies remained impractical due to demanding computational requirements (hundreds of years of computing resources) and unsuitability for collaborative settings (terabytes of data to share). In HD-READY, our previous JPND Working Group, we developed methods that successfully overcome both of these issues. However, one key outstanding issue in neuroimaging is that these high-dimensional phenotypes (i.e., voxels, vertices) require an dedicated approach to harmonization, since they are not straightforward to compare between neuroimaging studies. In the Full-HD Working Group, we focus on this harmonization of high-dimensional neuroimaging phenotypes in combination with other omics data, and how to make the resulting ultra-high-dimensional data easily accessible in neurodegeneration research.
Network JPco-fuND
Call Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration

Project partner

Number Name Role Country
1 Erasmus MC Coordinator Netherlands
2 Radboud University Partner Netherlands
3 Boston University School of Medicine Partner United States
4 Keck School of Medicine of the University of Southern California Partner United States
5 University Medicine Greifswald Partner Germany
6 University of California Partner United States
7 Medical University Graz Partner Germany
8 QIMR Berghofer Medical Research Institute Partner Australia