Project: Framework for Innovative Multi-tracer molecular Brain Imaging (IMBI) to enable multi-centre trials and image evaluation in (early) neurodegenerative diseases

Acronym IMBI (Reference Number: JPCOFUND_FP-940-016)
Duration 01/10/2016 - 31/03/2017
Project Topic Positron emission tomography (PET) is a highly sensitive method to detect disease specific molecular alterations in vivo. In neurodegenerative diseases (ND) PET may detect (i) protein deposition (amyloid, tau), (ii) chronic neuroinflammation (NI; microglia/astroglia), and (iii) changes of neurotransmission and -metabolism. The IMBI working group (WG) will bring together key experts from the field of PET imaging in ND. The hypothesis of the WG is that by employing innovative PET molecular markers it will be possible to image the hallmarks of ND at various disease stages, which will provide novel information on the ND course. This will enable both early disease detection and personalised implementation of ND modifying therapies. Based on previous/current European projects (FW5 NEST-DD; FW6 DiMI; FW7 INMiND) the aims of the WG are (A) to harmonise (i) multi-tracer PET protocols for multi-centre studies; (ii) PET acquisition and quantification of innovative molecular radiotracers; (iii) PET studies during various ND disease stages (early disease, therapy follow-up); (B) to harmonise the correlation of PET findings with soluble biomarkers and “omics” data (C) to coordinate work with other WGs on imaging/clinical trials in ND patients
Network JPco-fuND
Call Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration

Project partner

Number Name Role Country
1 Westfalian Wilhelms-University Münster (WWU) Coordinator Germany
2 K.U. Leuven Partner Netherlands
3 Aarhus University Partner Denmark
4 Region Hovedstaden Partner Denmark
5 University of Copenhagen Partner Denmark
6 Hospital District of Southwest Finland Partner Finland
7 Hospital District of Southwest Finland Partner Finland
8 University of Tours Partner France
9 University of Tours Partner France
10 University of Tours Partner France
11 Commissariat à l’Energie Atomique et aux Energies Alternatives Partner France
12 Commissariat à l’Energie Atomique et aux Energies Alternatives Partner France
13 Commissariat à l’Energie Atomique et aux Energies Alternatives Partner France
14 National Research Council Partner
15 Vita-Salute San Raffaele University Partner Italy
16 University of Milan, Bicocca Partner Italy
17 VU University Medical Center Partner Netherlands
18 VU University Medical Center Partner Netherlands
19 Academisch Ziekenhuis Groningen Partner Netherlands
20 Karolinska Institutet Partner Sweden
21 Karolinska Institutet Partner Sweden
22 Karolinska Institutet Partner Sweden
23 Karolinska University Hospital Huddinge Partner Sweden
24 Lund University Partner Sweden
25 The University of Manchester Partner United Kingdom
26 The University of Manchester Partner United Kingdom
27 The University of Manchester Partner United Kingdom
28 Imperial College London Partner United Kingdom
29 King’s College London Partner United Kingdom
30 King’s College London Partner United Kingdom
31 University of Newcastle Partner United Kingdom