Project: Diet-induced Arrangement of the gut Microbiome for improvement of Cardiometabolic health

Duration 01/06/2016 - 31/12/2019
Project Topic The communities of microorganisms in the mammalian intestine, referred to as the gut microbiota (or microbiome when describing their genomes), was recently recognized as an important factor influencing human health throughout all stages of life. A number of clinical conditions linked to chronic inflammatory and cardiometabolic disorders like obesity, type-2 diabetes and atherosclerosis are associated with dysbiotic microbial ecosystems in the gut, i.e., shifts in the structure and function of the microbiota. However, the characteristic features of dysbiotic gut communities are not very well defined. Certain gut microbial metabolites have been implicated in the onset of cardiometabolic disorders, but molecular mechanisms are poorly characterized and causal relationships have yet to be determined. Diet is a prime influencing factor of both the intestinal milieu and risks for developing cardiometabolic pathologies, but knowledge about the reciprocal interaction between specific dietary components and microbial populations is scant. The DINAMIC consortium will fill this gap by investigating interactions between diet, gut microbiota structure and function, and their role in the prevention of metabolic dysfunction and cardiovascular complications, thereby enabling new strategies for prevention and treatment of cardiometabolic diseases. The programme is based on: (i) state-of-the-art prospective and genetically well-characterized human cohorts to gain detailed insight into associations between dietary habits, the gut microbiome and cardiometabolic health parameters in adults subjects; (ii) targeted experimental approaches to study causal relationships between specific diet-derived microbial metabolites and the development of metabolic syndrome and atherosclerosis; and (iii) innovative dietary intervention and faecal transplant strategies for maintenance or restoration of metabolic and cardiovascular health. The work relies on established pipelines for assessment of 16S rRNA gene diversity and composition, as well as state-of-the-art metagenomics, metabolomics and data integration platforms. Hence, thanks to the complementary use of large-scale and targeted models, explorative and interventional approaches, as well as standardization efforts for leading-edge assessment of the gut microbiota, the DINAMIC team will deliver penetrating insights into nutritional strategies for modulation of the intestinal microbiome to promote metabolic and cardiovascular health.
Network JPI HDHL

Project partner

Number Name Role Country
1 TU Munich Coordinator Germany
2 TU Munich Partner Germany
3 University College Cork Partner Ireland
4 Université d'Auvergne Clermont Partner France
5 University of Naples Federico II Partner Italy
6 Amsterdam Diabetes Center AMC-VUmc Partner Netherlands
7 University of Copenhagen Partner Denmark
8 INRA Partner France
9 King's College Hospital Partner United Kingdom
10 Helmholtz Zentrum München Partner Germany