Project: Aryl hydrocarbon receptor and immunity: Activation by diet, microbiota and probiotics
| Acronym | AryIMUNE |
| Duration | 01/01/2016 - 31/12/2019 |
| Project Topic | The aryl hydrocarbon receptor (AhR) is a transcription factor involved in the toxicity of xenobiotics but it has recently been shown to be a key determinant of intestinal homeostasis by promoting the local production of IL22 and the maintenance of intraepithelial lymphocytes. In the gastrointestinal tract, AhR activators originate from the diet or from the microbiota. Indole-3-carbinol, present in cruciferous vegetables, is converted by stomach acid into AhR agonists. Dietary tryptophan is metabolized by gut bacteria into indole derivatives that are AhR ligands. Finally some probiotic bacteria produce AhR agonists. |
| Network | JPI HDHL |
| Call | MICROBIOMICS |
Project partner
| Number | Name | Role | Country |
|---|---|---|---|
| 1 | Universite Pierre et Marie Curie | Coordinator | France |
| 2 | McMaster University | Partner | Canada |
| 3 | Micalis Institute, INRA | Partner | France |
| 4 | Wageningen University | Partner | Netherlands |