Project: Systems biology of bacterial methylotrophy for biotechnological products from methanol

Genetically engineered bacteria are widely used as cell factories for production of special, fine, bulk, and fuel chemicals. Industrial biotechnology mainly uses sugars and molasses as carbon source, and these raw materials are derived from plants demanding cultivable land which is more and more needed for human nutrition. Methanol is abundant and regarded as alternative highly attractive non-feed raw material in microbial bioprocesses. Methylotrophy, the ability of certain specialized bacteria to use methanol as carbon source for growth, bears the potential to build value from methanol through production of value-added chemicals. A systems-level understanding of bacteria is a prerequisite for their rational engineering and efficient use as cell factories in industrial biotechnology. The MetApp project goal is to gain systems-level understanding of evolutionary alternatives of bacterial methylotrophy to deduce and experimentally evaluate strategies for methanol-based production of sought-after chemicals.

Acronym MetApp
Duration 01/12/2014 - 30/11/2017
Website visit project website
Network ERASysAPP
Call ERASysAPP 1st Call

Project partner

Number Name Role Country
SINVENT AS Norway
Swiss Federal Institute of Technology in Zurich Switzerland
SINTEF Materials and Chemistry Coordinator Norway
Institut National des Sciences Appliquées de Toulouse France
Bielefeld University Germany