Project: Integrating Modelling of Metabolism and Signalling towards an Application in Liver Cancer

Uncontrolled proliferation in cancer results from synergistic adaptations in metabolism and signalling. However, due to the complexity, coupling mechanisms between metabolism and signalling are difficult to assess and it remains to be clarified how they give rise to cooperative enhancement. As a proof of concept, we focus on liver cancer, and propose a combined experimental and modelling approach that exploits both, comprehensive genome-scale models to identify global, cancer-specific alterations as well as a more detailed integrative model that links glycolysis and signalling. We will develop standard operating procedures for combined quantitative studies of metabolism and signal transduction in healthy and cancer cells, elucidate alterations in signalling and gene expression causing glycolytic adaptations and predict cancer-cell selective drug combinations using mathematical modelling of healthy and cancer cells. The proposed approach will act as a model study for systems biology approaches to integrate metabolism and signalling in oncology and will open new avenues for the treatment of liver cancer.

Acronym IMOMESIC
Duration 01/03/2015 - 28/02/2018
Website visit project website
Network ERASysAPP
Call ERASysAPP 1st Call

Project partner

Number Name Role Country
German Cancer Research Center Coordinator Germany
VU University Amsterdam - Technology Transfer Office Netherlands
Charité University Medicine Berlin Germany
Chalmers University of Technology Sweden
Albert-Ludwigs University Freiburg Germany
Griffin Discoveries Netherlands
VU University Amsterdam Netherlands