Project: Systematic Rebuilding of Actinomycetes for Natural Product Formation

There is an urgent need for novel antibiotics to fight life-threatening infections and to counteract the increasing problem of propagating antibiotic resistance. Recently, new molecular genetic and biochemical tools have provided insight into the enormous unexploited genetic pool of environmental microbial biodiversity for new antibiotic compounds. New tools for more efficiently lifting this hidden treasure are needed to strengthen competitiveness of European industry, as well as for a cost-saving medical service for European citizens. The SYSTERACT project aims to develop the model Actinobacterium Streptomyces coelicolor into a 'Superhost' for the efficient production of antibiotic compounds, enabling a faster discovery of new antibiotics from environmental microbial resources. Central to this approach will be an iterative Systems Biology cycle, combining microbiology, genetics, biochemistry, and fermentation technology with predictive modelling. SYSTERACT brings together six partners from four ERASysApp member countries, including four universities, one non-profit research organization, as well as the latter's Technology Transfer Unit. Strong relevant industry is closely connected to the project and supports the research partners in their efforts to develop a reliable new tool by a Systems Biology approach that is useful for a more efficient discovery of new future antibiotics.

Duration 01/12/2015 - 30/11/2018
Website visit project website
Network ERASysAPP
Call 2nd Joint Call for Applied Systems Biology Research

Project partner

Number Name Role Country
SINTEF Materials and Chemistry Coordinator Norway
University of Rostock Germany
Eberhard Karls University of Tubingen Germany
Leiden University Netherlands
Chalmers University of Technology Sweden