Project: Patient-Reported Outcome, Biodata and Process Data to Evaluate Dialysis Tolerability

Acronym ProDial (Reference Number: ERAPERMED2019-155)
Duration 01/04/2020 - 31/03/2023
Project Topic Haemodialysis treatment affects around 0.1% of the population. However, this complex, longstanding and chronic patient care requires 5 to 10% of overall health costs in developed countries, assures life-sustaining patient detoxification but at the same time cannot ameliorate 5-10-fold mortality excess in end-stage renal disease patients compared to general population. Quality and process control of haemodialysis treatment is nowadays based on non-individual assessment of biochemical and procedural dialysis measures, not impacting the patient outcome regarding mortality and dialysis tolerability. This proposal aims at developing an individual dialysis analysis and personalized data generation and handling scheme to characterize: (I) the patients’ surrogate biodata of sympathetic activation following dialysis treatment (continuous heart rate variability), physical activity (step-count), sleep quality and dialysis recovery time (movement analysis) (II) a self-reported tolerability outcome (recovery time, dialysis fatigue, sleep quality) and (III) dialysis machine generated data (ultrafiltration, session time, blood pressure, blood volume) with the potential to influence treatment outcome and tolerability. Innovative, anonymized and nontrackable data procedures including wearable personal devices and sensors shall assure integrated, searchable and personalized data storage. Innovative mechanisms to find associations between the referenced data categories (self-reported outcome, biodata, machine data) will ensure the upcoming development of personalized, real-time dialysis treatment procedures. Those algorithms build on data read-outs can be integrated in future smart dialysis facilities to enable personalized real-time variable treatment to respond to individual comorbidity and tolerability behaviour of patients.
Network ERA PerMed
Call 2nd Joint Transnational Call for Proposals (2019)

Project partner

Number Name Role Country
1 Innovation Center Computer Assisted Surgery (ICCAS) - Medical Faculty - Leipzig University (ULEI) Coordinator Germany
2 Martin-Luther-Universität Halle-Wittenberg Partner Germany
3 Sigmund-Freud-University Wien Partner Austria
4 Wroclaw Medical University Partner Poland
5 Medifina GmbH Partner Austria