Project: Targeting subclinical motor and cognitive impairment in patients with early onset Multiple Sclerosis at high Risk of disEase activity through a preventive personaLised and InnovAtive rehaBiLitation stratEgy

Acronym	RELIABLE (Reference Number: ERAPERMED2022-295)
Duration	01/03/2023 - 28/02/2026
Project Topic	Prevention of disease worsening from the earliest stages of the disease is an important unmet need in Multiple Sclerosis (MS). In this study we will focus on a comprehensive assessment of subclinical deficits in patients without clear evidence of neurological dysfunction. Applying personalized interventions targeted to the subject deficits may reduce the burden of these deficits, improve the subject quality of life and possibly reduce the chance of future, clinically evident, disability accrual. The aim of this pilot study is to assess the subclinical burden of neurological impairments in early Relapsing-Remitting MS patients with no evident neurological disability (Expanded Disability Status Scale, EDSS, score of 2.0 points or less) by applying a comprehensive assessment including comorbidities, lifestyle, imaging, neuropsychological, gait and balance analyses. From these analyses, we will obtain a risk score for disability worsening over the short-term (1 year). We will then evaluate in a validation cohort the reduction of the rate of patients with evidence of disease activity using a comprehensive and personalized approach (lifestyle counselling, advanced motor and cognitive rehabilitation). As an added value, we will take into account patient preferences and values to support tailoring the interventions.
Network	ERA PerMed
Call	5th Joint Transnational Call for Proposals (2022)

Number	Name	Role	Country
1	IRCCS Fondazione Don Carlo Gnocchi ONLUS	Coordinator	Italy
2	Sheba medical center	Partner	Israel
3	Uppsala University	Partner	Sweden
4	Careggi University Hospital	Partner	Italy