Project: Deciphering the role of peripheral and central nervous system metabotropic glutamate receptors in neurophatic pain with photoactivable ligands

Optogenetic approaches are viewed as very promising approaches to tackle physiological processes, and eventually for space and time-controlled therapeutic interventions. However, the need for transgenes limits the development of these approaches. An alternative is based on optopharmacology, which consists of using light-activable compounds that can reach their target only upon light activation. The LIGHTPAIN project is aimed at developing photo-activable ligands targeting selectively metabotropic glutamate (mGlu) receptors, which represent promising drug targets for pain control. The ultimate objectives are directed to understand the role of the different mGlu receptor subtypes at different sites of the nervous system in regulating pain transmission. These light-controlled molecules and the techniques for optical ligand delivery to the spinal cord, brain and peripheral nerves will be used to understand how mGlu receptors critically regulate pain threshold under pathological conditions. The LIGHTPAIN project specifically addresses this issue using subtype-selective mGlu receptor ligands ( positive or negative allosteric modulators) that are photochemically triggered and can therefore interact with mGlu receptors only at sites (peripheral or central) that are spatiotemporally exposed to light.

Duration 01/04/2013 - 01/04/2016
Call Novel Methods and Approaches towards the Understanding of Brain Diseases

Project partner

Number Name Role Country
1 Agencia Estatal Consejo Superior de Investigaciones Cientificas, CSIC Coordinator Spain
2 Universitat Autònoma de Barcelona Partner Spain
3 Universitat de Barcelona Partner Spain
4 IRCCS Partner Italy
5 CNRS Partner France