Project: Trained iMmunity in bonE MarrOw progenitors as dRiver of atherosclerosis in obesitY

Acronym MEMORY
Duration 01/05/2019 - 30/04/2021
Project Topic Due to the worldwide adoption of Western lifestyle, the prevalence of obesity increases exponentially. Obesity is an important risk factor for atherosclerotic cardiovascular disease, including heart attacks and strokes. The ultimate aim of this proposal is to understand how Western type diet and obesity induce atherosclerosis. We focus on the innate immune system, since this importantly contributes to atherosclerosis and we have recently shown that substances that can induce cardiovascular disease (such as cholesterol particles) can lead to a long-term activation of the innate immune system. We propose that Western type diet and obesity changes the development of the innate immune system in the bone marrow in such a way that they are prone to stimulate the development of atherosclerosis. Our results potentially can reveal novel mechanism that contribute to cardiovascular disease in subjects with obesity that can be used to develop novel drugs to prevent these diseases
Network ERA-CVD
Call Joint Transnational Call for Proposal 2018 (JTC 2018)

Project partner

Number Name Role Country
1 Radboud University Medical Center Coordinator Netherlands
2 University of Bonn Partner Germany
3 St-Antoine Hospital and Inserm Partner France