Project: NEural MOdulation of IMMUNE system to shape cardiac remodeling to chronic arterial hypertension and counteract Heart Failure

Acronym	NEMO-IMMUNEagainstHF
Duration	01/05/2019 - 30/04/2021
Project Topic	Hypertensive heart disease is one of the leading causes of disability and death associated with high blood pressure. When it becomes chronic, it leads to heart failure with a preserved ejection fraction and it could even worsen left ventricle function, leading to reduced ejection fraction. The cardiac remodeling as a result of hypertensive heart disease, may be caused by different components mutually interacting. We recently discovered that the autonomic nervous system (ANS), the main regulator of cardiac function, modulates immune functions involved in cardiovascular diseases. Since immune cells and burden of inflammation in pericardial adipose tissue (PAT) control myocardium’s ability to withstand hypertension, our hypothesis is that neuroimmune interactions are required to shape left ventricle adaptive responses to hypertension. The network of this project will connect combined expertise to address how autonomic nervous system modulations, immune cells and pericardial adipose tissue, modulate cardiac scenario during hypertension, and how they influence the development of heart failure, trying to translate the results to human pathology.
Network	ERA-CVD
Call	Joint Transnational Call for Proposal 2018 (JTC 2018)

Number	Name	Role	Country
1	IRCCS Neuromed	Coordinator	Italy
2	Toronto General Hospital Research Institute	Partner	Canada
3	Ludwig-Maximilians-University,	Partner	Germany
4	Jagiellonian University Medical College	Partner	Poland