Project: Investigating long non-coding RNA regulated pathways driving cardiac regeneration

Duration 01/05/2019 - 30/04/2021
Project Topic One of the main causes underlying the high death toll of cardiovascular disease is the lack of significant cardiac regeneration of the adult heart. In marked contrast, for a short period of time after birth, newborn mice and possibly humans can fully regenerate the heart after a heart attack. INNOVATION aims to decipher the molecular circuitries underlying the striking difference between newborn heart regeneration and fibrotic infarct healing of the adult heart. INNOVATION particularly focuses on the “dark matter” of the genome which is, among other forms of RNA, comprised of tens of thousands long non-coding RNA (lncRNA). Although relatively unexplored, it has become evident that lncRNAs are required for the establishment and maintenance of normal gene expression networks, thus controlling developmental and disease processes. Our main goal is to identify lncRNA signatures in the newborn heart that can be exploited to devise novel regenerative strategies in the adult and in particular the diseased heart.
Network ERA-CVD
Call Joint Transnational Call for Proposal 2018 (JTC 2018)

Project partner

Number Name Role Country
1 Hannover Medical School Coordinator Germany
2 VU University Medical Center Partner Netherlands
3 Innsbruck Medical University Partner Austria
4 IRCCS Istituto Clinico Humanitas Partner Italy
5 IBIMED, University of Aveiro Partner Portugal