Project: Investigating DETerminants of atrial Electrical ConducTion underlying ARRHYTHMIAS

Acronym	DETECT ARRHYTHMIAS
Duration	01/05/2019 - 30/04/2021
Project Topic	Arrhythmias are one of the major healthcare challenges since they are affecting millions of Europeans and are associated with significant morbidity and mortality. Current treatment options have to be improved by innovative therapies that are ideally targeting causal proarrhythmic mechanisms. DETECT ARRHYTHMIAS is based on the hypothesis that cardiomyocytes are not the exclusive determinants of electrical conduction properties. The consortium will therefore investigate the cardiac “interactome” and its effects on physiologic impulse generation and propagation through the heart as well as on pathophysiologic mechanisms leading to arrhythmias. To this purpose we will study (epi)genetic, metabolic, electrophysiologic and immunologic factors on the level of individual myocardial cells, neighboring cells within the myocardium, and cells originating from outside of the myocardium.
Network	ERA-CVD
Call	Joint Transnational Call for Proposal 2018 (JTC 2018)

Number	Name	Role	Country
1	Klinikum der Universität München	Coordinator	Germany
2	IRCCS Cardiologico Monzino	Partner	Italy
3	Yeditepe University	Partner	Türkiye
4	University of Tartu	Partner	Estonia