Project: Standardisation of concentration measurements of extracellular vesicles for medical diagnoses
| Acronym | METVES II (Reference Number: 18HLT01) |
| Duration | 01/06/2019 - 31/05/2022 |
| Project Topic | Early diseases diagnosis is generally advantageous for patients compared to late-stage interventions, providing better clinical outcomes. In addition, treatment costs can be significantly lower than treatments after late-stage diagnoses. Clinicians can identify many types of diseases by testing for so-called biomarkers in various body fluid types, including blood, using the flow cytometry (FCM) technique. Extra-cellular vesicles (EVs), that are present in many body fluids, offer potential as a new biomarker. Flow cytometry (FCM) instrumentation, however, needs calibration with reference materials to make EV measurements comparable, so clinicians can be confident in this biomarker in diagnostics. This project aims to improve the accuracy of flow cytometry methods for extra-cellular vesicle measurements to validate this biomarker for reliable clinical use. Well-characterised, synthetic reference materials mimicking EV properties and related measurement methods will be developed to enable more harmonised FCM calibration. The project will deliver better diagnostics for patients and support development of new measurement facilities at National Measurement Institutes and Designated Institutes across Europe. |
| Website | visit project website |
| Network | EMPIR |
| Call | EMPIR Call 2018 |
Project partner
| Number | Name | Role | Country |
|---|---|---|---|
| 1 | VSL B.V. | Coordinator | Netherlands |
| 2 | Bundesanstalt fuer Materialforschung und -pruefung | Partner | Germany |
| 3 | LGC Limited | Partner | United Kingdom |
| 4 | Laboratoire national de métrologie et d'essais | Partner | France |
| 5 | Physikalisch-Technische Bundesanstalt | Partner | Germany |
| 6 | Teknologian tutkimuskeskus VTT Oy | Partner | Finland |
| 7 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Partner | Netherlands |
| 8 | Exometry B.V. | Partner | Netherlands |
| 9 | Magyar Tudományos Akadémia Természettudományi Kutatóközpont | Partner | Hungary |
| 10 | Helsingin Yliopisto | Partner | Finland |
| 11 | BD Switzerland Sàrl | Observer | Switzerland |
| 12 | PolyAn Gesellschaft zur Herstellung von Polymeren für spezielle Anwendungen und Analytik mbH | Observer | Germany |