An effective monitoring and evaluation system requires continuous data collection based on clear indicators. Partnerships should implement streamlined and continuous monitoring to collect the right data at the right time. The Revised Research and Innovation Partnership Evaluation (R²IPE) toolkit provides guidance on monitoring systems, intervention logic, evaluation timing and questions, data collection and analysis. Evaluations may be formative (improving implementation) or summative (assessing outcomes), and they should be supported by robust data and independent expertise. Partnership‑specific impact pathways and key performance indicators should align with the Horizon Europe Key Impact Pathways and be integrated into lifecycle plans.