Project: An integrated european platform to conduct translational studies in myelodysplastic syndromes based on the EuroBloodNet infrastructure

Acronym	Euro MDS (Reference Number: TRS-2018-00000745)
Duration	01/04/2019
Project Topic	RATIONALE. Myelodysplastic syndromes (MDS) are rare cancers with unmet medical needs. Study of MDS has been rapidly transformed by genome characterization. HYPOTHESIS. We hypothesize that comprehensive analyses of large patient population will allow to correctly estimate the effect of each mutation on clinical outcomes, and that niche factors and immune dysfunctions may influence the development of MDS, clonal evolution and response to treatments AIMS. 1- Investigate gene mutations, niche factors and immune dysfunctions influencing the development of MDS, and define biomarkers for early identification of individuals at risk; 2- Develop prognostic models for MDS patients through integration of comprehensive genomic/clinical information; 3- Define biomarkers to better stratify the individual probability of response to specific treatments METHODS. EuroBloodNet, the European Reference Network in rare hematological diseases, will provide a basis for research activities - AIM1: study of genomic features of clonal dominance in elderly subjects enrolled in 3 large population-based studies and description of the dynamics of clonal establishment and evolution; study of bone marrow microenvironment to identify immune dysfunctions influencing MDS development - AIM2: development of inclusive statistical models to accurately predict clinical outcome at individual level, based on large MDS populations with comprehensive genomic/clinical data - AIM3: analysis of mutational screening and immune profiles from patients enrolled in prospective trials, to provide evidence on genetic/immunologic profiles associated with probability of response to specific compounds EXPECTED RESULTS. To characterize how clonal hematopoiesis relates to the induction of MDS clinical phenotype, and to test the utility of gene sequencing to detect subjects at risk of developing MDS. To define effective prognostic systems and biomarkers to stratify the individual probability of response to treatment
Network	TRANSCAN-2
Call	4th Joint Transnational Call (JTC 2017)

Project partner

Number	Name	Role	Country
1	IRCCS Humanitas Research Hospital	Coordinator	Italy
2	Hôpital St Louis / Université Paris 7	Partner	France
3	Technical University of Dresden	Partner	Germany
4	Josep Carreras Leukaemia Research Institute (IJC)	Partner	Spain