Project: Maternal obesity and cognitive dysfunction in the offspring: cause-effect role of the GUT MicrobiOMe and early dietary prevention

Acronym GUTMOM
Duration 01/03/2018 - 31/05/2022
Project Topic Early life is fundamental for brain and microbiota development. Gut microbiota influences brain function. Maternal obesity affects maturation of gut microbiota and is an important predictor of cognitive dysfunction in the offspring. Cognitive decline through life is an increasingly invalidating condition, due to population ageing and the high frequency of predisposing factors (obesity, unhealthy diets). We hypothesize that the negative effects of maternal obesity on cognitive function in the offspring are partly mediated by the microbiota and its metabolites, offering the opportunity for non-invasive risk-screening and -reduction by tailored foods and diets, since earliest life stages. We use two existing cohorts of children to identify the gut bacteria and metabolites that are related to maternal obesity and offspring’s cognitive development in early, pre-scholar and scholar age. We use preclinical models to investigate cause-effect mechanisms, and develop tailored dietary interventions to counteract the effects of maternal obesity on the gut microbiota, improving offspring’s cognition. GUTMOM involves 6 academic centres, and a private industrial collaborator providing project co-funding. The plan includes dissemination and training activities for young scientists. Data management will follow the FAIR principles, and the study will contribute to the ongoing Knowledge Platform on Diet, Intestinal Microbiomics and Health.
Website visit project website
Call HDHL-INTIMIC Cofunded Call "Interrelation of the Intestinal Microbiome, Diet and Health"

Project partner

Number Name Role Country
1 Consiglio Nazionale delle Ricerche - CNR Coordinator Italy
2 University of Valencia Partner Spain
3 Radboud UMC Partner Netherlands
4 Max Planck Gesellschaft Partner Germany
5 University of Helsinki Observer Finland
6 Istituto Superiore di Sanità Observer Italy
7 Mead Johnson Nutrition Observer Netherlands