Project: Impact of MEditerranean Diet, Inflammation and Microbiome on plaque vulnerability and microvascular dysfunction after an Acute Coronary Syndrome. A randomized, controlled, mechanistic clinical trial

Acronym MEDIMACS (Reference Number: JTC-2017-11)
Duration 01/01/2018 - 31/12/2020
Project Topic What: Coronary atherosclerosis is a leading cause of mortality and disability worldwide. Continuous efforts are needed to improve secondary prevention and understand the mechanism underlying disease progression. Based on primary prevention trials, a potential benefit of the Mediterranean diet after an acute coronary syndrome can be anticipated. The integrated microbiome-mediated/immunologic and metabolic pathways by which the Mediterranean diet modifies cardiovascular risk remain mostly unknown. Intestinal and oral dysbiosis is involved in the pathogenesis of atherosclerosis and microbiome dynamics may account for some of the observed benefits of Mediterranean diet. How: The first objective of MEDIMACS is to evaluate the effects of a well-controlled Mediterranean diet intervention on atherosclerotic plaque vulnerability and coronary endothelial dysfunction after an episode of acute coronary syndrome. The second objective is to decipher the interplays among diet, microbiota, immunity and metabolism responsible for the observed effects. Therefore, a randomized mechanistic clinical trial, using state-of-the-art efficacy read-outs is proposed. This study will provide valuable insights to identify potential microbiome therapeutic targets for coronary artery disease. Who: The MEDIMACS consortium consists of four partners, coordinated by Francisco Fernández-Avilés, CIBER (Spain); email contact: The other consortium partners are Dominique Charron and Reem Al-Daccak, Université Paris-Diderot and INSERM (France), Uri Gophna, Tel Aviv University (Israel) and Edward Moore, University of Gothenburg (Sweden).
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Call HDHL-INTIMIC Cofunded Call "Interrelation of the Intestinal Microbiome, Diet and Health"

Project partner

Number Name Role Country
1 Centro de Investigación Biomédica en Red (CIBER) Coordinator Spain
2 HLA-MED Partner France
3 Tel Aviv University Partner Israel
4 University of Gothenburg Partner Sweden