Project: Modulating BRICHOS for an Alzheimer’s Therapy

Acronym BrichosPharm (Reference Number: 12257)
Duration 01/10/2018
Project Topic Alzheimer’s disease (AD) is thought to be caused by aggregation and neurotoxicity of Abeta (Ab) proteins. We have discovered a pathway to prevent Ab aggregation via a natural human protein domain, called Bri2 BRICHOS (BD). Here we will deliver a) in vivo data to show that BD can prevent accumulation of toxic Ab intermediates and thereby prevent or slow AD and b) small molecules that bind BD and unleash its protective activity.
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Network Eurostars 2
Call Eurostars Cut–off 9

Project partner

Number Name Role Country
1 ZoBio BV Coordinator Netherlands
2 Neurobiology, care sciences and society department at Karolinska Institutet Partner Sweden