Project: Development of a novel allosteric modulator to treat post-traumatic stress disorder

Acronym DiSARM FEAR (Reference Number: 113468)
Duration 15/10/2019 - 17/10/2022
Project Topic The consortium will deliver DiSARM FEAR, a novel clinical candidate for Post-Traumatic Stress Disorder (PTSD), by developing small-molecule negative allosteric modulators (NAMs) targeting the metabotropic glutamate receptor 7 (mGluR7) to reduce fear memory reconsolidation. We will generate a lead and perform pharmacology, ADME/PK, non-GLP toxicity and efficacy studies in new PTSD models. After the project, DiSARM FEAR will complete preclinical development and enter clinical trials.
Network Eurostars 2
Call Eurostars Cut–off 11

Project partner

Number Name Role Country
1 Addex Pharma SA Coordinator Switzerland
2 Naason Science Inc. Partner Korea, Republic of
3 Endotherm GmbH Partner Germany
4 Nucro-Technics, a Division of the Vimy Ridge Group Ltd. Partner Canada
5 Stichting Katholieke Universiteit - Radboud University Nijmegen Partner Netherlands