Project: In-joint application of non-viral mRNA therapy for osteoarthritis

Acronym JOINT-APPROACH (Reference Number: 12792)
Duration 01/05/2019 - 03/05/2022
Project Topic We will develop a novel safe (non-viral) and effective gene therapy-like mRNA therapy for osteoarthritis (OA). Using unique in-joint injectable polymer-based nanoparticle carriers, intracellular delivery of mRNA into joint-related tissues can be ensured. This therapy will suppress inflammation and support cartilage and tendon tissue regeneration. The project will perform the preclinical development to generate proof-of-concept, required for subsequent regulatory pre- and clinical validation.
Network Eurostars 2
Call Eurostars Cut–off 10

Project partner

Number Name Role Country
1 20Med Therapeutics BV Coordinator Netherlands
2 Ethris GmbH Partner Germany
3 AO Research Institute Davos Partner Switzerland
4 Paracelsus Medical University Partner Austria