Project: Novel genomic switches for 2nd generation in vivo models of human disease

Acronym SwitchItOn (Reference Number: 11304)
Duration 01/11/2017
Project Topic New genomic switches will be developed which will allow to turn on/off multiple (trans)genes independently of each other in vivo. First prototypes of three inducible systems are available, E-Rex, Phlo, & RuX, which can regulate gene expression by adding erythromycin (Ery), phloretin (Phlo) or RU486 to the system. In order to bring these expression systems to the market, all three systems need optimization in terms of increasing tightness, inducibility, sensitivity and reversibility.
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Network Eurostars 2
Call Eurostars Cut-Off 7

Project partner

Number Name Role Country
1 PolyGene AG Coordinator Switzerland
2 Intelligent Pharma Partner Spain
3 TargetEx Kft. Partner Hungary
4 University Zürich Partner Switzerland