Project: Systems Medicine-based clinical decision support for COPD patients

Acronym SysMed-COPD (Reference Number: JTC2_35)
Duration 01/07/2018 - 30/06/2022
Project Topic Chronic obstructive pulmonary disease (COPD) claimed 3.2 million lives in 2015, making it the third cause of death worldwide. It ispredicted to increase in coming years due to aging populations and thus constitutes an enormous socio-economic burden.Existing assessment strategies neglect the complex, multi-component, and heterogeneous pathophysiology, as well as manifoldcomorbidities (cardiovascular, metabolic etc.). Therefore, improved COPD diagnosis and classification constitutes an urgent medical needfor improved and personalized prevention measures and treatments strategies.The main aim of our project is to develop a tool that will enable effective preventive measures and personalize treatment strategies forCOPD by means of systems medicine. This transnational and interdisciplinary project combines clinical scientists, experimentalists,computational and systems biology researchers, as well as a medium sized company. We will develop a systems medicine model ofCOPD constructed on (i) machine learning clustering of two comprehensive patient cohorts (COSYCONET, CIRO) providing long-term clinicalobservations, systematic outcome evaluation, biomaterial collections, multiple laboratory measurements, and extensive imaging data ofmore than 6,000 patients, complemented by (ii) an iterative systems biology framework of modeling and experimental analysis. Based onthis multi-scale systems medicine model, we will generate a novel Clinical Decision Support (CDS) software that we will evaluate for patientcare in the existing IT infrastructure of hospitals and private practices.As a prototypic demonstrator of applied systems medicine modeling, our tool will enablei) individual and comprehensive treatment and prevention measures for COPD patientsii) significant reductions of socio-economic costs due to less mortality and disabilityiii) novel insights in the dysregulation of metabolism, immunology and aging in COPD from the underlying model.
Network ERAcoSysMed
Call 2nd Joint Transnational Call for European Research Projects on Systems Medicine

Project partner

Number Name Role Country
1 Philipps-University Coordinator Germany
2 Philipps-University Partner Germany
3 Norwegian University of Science and Technology (NTNU) Partner Norway
4 Viscovery Software GmbH Partner Austria
5 Maastricht University Medical Center Partner Netherlands
6 CIRO, center of expertise for chronic organ failure (external collaborator) Observer Netherlands