Project: SALivAry bioMarkers of mediterraneAN Diet associated with long-tERm protection against type 2 diabetes mellitus

WHAT: Saliva offers the advantages of simple and non-invasive sampling and is a rich source of biomarkers thanks to the high diversity of its microbiome, proteome and metabolome. Saliva composition is also dependent on diet. The SALAMANDER project aims at identifying and validating salivary signatures indicative of healthy dietary choices (adherence to a Mediterranean diet) with a positive long-term health outcome (protection against T2DM). WHO: SALAMANDER brings together partners from France, the United Kingdom and Spain: Institut National de la Recherche Agronomique (Martine Morzel, coordinator, the Centre for Taste and Feeding Behaviour), Université de Bordeaux (Catherine Féart, Bordeaux Population Health), King’s College London (Gordon Proctor, Dental Institute) and Universidad Autónoma de Madrid (Fernando Rodríguez-Artalejo, Cardiovascular and Nutritional Epidemiology group). HOW: Using the UKBiobank resource, subjects will be categorized based on their health status (T2DM) and diet. The saliva microbiome, proteome and metabolome of selected subjects will be analyzed, and analytical data integrated to define a multimarker signature of a healthy Mediterranean diet associated with protection against T2DM. The validation phase will also include elderly subjects of the ENRICA and 3City-Bordeaux cohorts, to verify whether such signatures are conserved with ageing.

Acronym	SALAMANDER (Reference Number: 564)
Duration	01/03/2017 - 01/03/2020
Network	ERA-HDHL
Call	Call for Joint Transnational Research Proposals: Biomarkers for Nutrition and Health

Project partner

Number	Name	Role	Country
1	Institut National de la Recherche Agronomique UMR6265 CNRS, UMR1324 INRA, Université de Bourgogne	Coordinator	France
2	King's College London	Partner	United Kingdom
3	Université de Bordeaux	Partner	France
4	Universidad Autónoma de Madrid	Partner	Spain