Project: Oxylipins signature to monitor the cardiometabolic status and its response to dietary intervention

WHAT: There is an urgent need to find reliable early biomarkers of the cardiometabolic syndrome (CardMetS) allowing intervention before irreversible damage develops while assessing the efficacy of nutritional prevention. Targeted lipidomic profiling of oxylipins could provide relevant candidate biomarkers. Our main objective is to uncover and validate the oxylipin signatures reflecting the trajectory from health to CardMetS and its relationships with diet. WHO: The OXYGENATE project gathers complementary and multidisciplinary expertise in: • Nutrition: o Dr C Gladine, INRA, France o Dr A Astrup & L H Larsen, UCPH, Denmark • Analytical chemistry/lipidomics: o Dr N Schebb, Univ. Wuppertal, Germany o Dr J Newman, UC Davis, USA • Nutritional epidemiology and cardiometabolic health: o Dr M Touvier, INSERM, France o Dr A Szuba, Univ. Wroclaw, Poland HOW: Using an optimized targeted lipidomic approach and leveraging 2 independent prospective cohorts (i.e. the Polish PURE and the French NutriNet-Santé cohorts) and 2 whole-diet interventions (Shopus and iMAPS) we will identify and validate oxylipin signatures (i) differentiating individuals at different stages of CardMetS and with different dietary patterns and (ii) evolving consistently with dietary interventions affecting the cardiometabolic endpoints.

Acronym OXYGENATE (Reference Number: 579)
Duration 01/03/2017 - 01/03/2020
Network ERA-HDHL
Call Call for Joint Transnational Research Proposals: Biomarkers for Nutrition and Health

Project partner

Number Name Role Country
1 INRA/UMR 1019 Human Nutrition Coordinator France
2 Centre de Recherche en Épidémiologies et Biostatistiques Sorbonne Paris Cité, Inserm U1153 /Inra 1125/Cnam/Université Paris 13 Partner France
3 University of Copenhagen Partner Denmark
4 University of Wuppertal Partner Germany
5 Wroclaw Medical University Partner Poland