Project: Oxylipins signature to monitor the cardiometabolic status and its response to dietary intervention

WHAT: There is an urgent need to find reliable early biomarkers of the cardiometabolic syndrome (CardMetS) allowing intervention before irreversible damage develops while assessing the efficacy of nutritional prevention. Targeted lipidomic profiling of oxylipins could provide relevant candidate biomarkers. Our main objective is to uncover and validate the oxylipin signatures reflecting the trajectory from health to CardMetS and its relationships with diet. WHO: The OXYGENATE project gathers complementary and multidisciplinary expertise in: • Nutrition: o Dr C Gladine, INRA, France o Dr A Astrup & L H Larsen, UCPH, Denmark • Analytical chemistry/lipidomics: o Dr N Schebb, Univ. Wuppertal, Germany o Dr J Newman, UC Davis, USA • Nutritional epidemiology and cardiometabolic health: o Dr M Touvier, INSERM, France o Dr A Szuba, Univ. Wroclaw, Poland HOW: Using an optimized targeted lipidomic approach and leveraging 2 independent prospective cohorts (i.e. the Polish PURE and the French NutriNet-Santé cohorts) and 2 whole-diet interventions (Shopus and iMAPS) we will identify and validate oxylipin signatures (i) differentiating individuals at different stages of CardMetS and with different dietary patterns and (ii) evolving consistently with dietary interventions affecting the cardiometabolic endpoints.

Acronym	OXYGENATE (Reference Number: 579)
Duration	01/03/2017 - 01/03/2020
Network	ERA-HDHL
Call	Call for Joint Transnational Research Proposals: Biomarkers for Nutrition and Health

Project partner

Number	Name	Role	Country
1	INRA/UMR 1019 Human Nutrition	Coordinator	France
2	Centre de Recherche en Épidémiologies et Biostatistiques Sorbonne Paris Cité, Inserm U1153 /Inra 1125/Cnam/Université Paris 13	Partner	France
3	University of Copenhagen	Partner	Denmark
4	University of Wuppertal	Partner	Germany
5	Wroclaw Medical University	Partner	Poland