Project: Gut Metabotypes as Biomarkers for Nutrition and Health

WHAT: Health reflects a balanced condition of all our eukaryontic cells and all the microbes living in and on our human body. In contrast, for many different disease entities it has been shown that the host-microbiome axis is dysregulated. Since the gut microbiome is known to be heavily influenced by diet, a balanced and symbiotic interplay between gut bacteria and the human organism might be a promising indicator for nutrition and health. WHO: Our consortium combines two groups with access to large and well characterized human cohorts (Matthias Laudes, Kiel (Germany) and Jane Shearer, Calgary (Canada)) and two well established groups in Metabolomics experienced in liquid chromatography, mass spectrometry (LC-MS) and matrix assisted laser desorption ionization-time of flight (MALDI-TOF) based approaches (Karin Schwarz, Kiel (Germany) and Harald Koefeler, Graz (Austria)). HOW: Identification of bacterial metabolites in the human serum as markers for nutrition and health using a three step program: 1. Identification of biopatterns of gut bacterial metabolites in the human serum, 2. Validation of the identified biopatterns in two independent international cohorts and in the same cohort at different time points, and 3. Verification of the eligibility of the biopatterns as indicators for nutrition and health in two human intervention studies.

Acronym BioNUGUT (Reference Number: 569)
Duration 01/03/2017 - 01/03/2020
Network ERA-HDHL
Call Call for Joint Transnational Research Proposals: Biomarkers for Nutrition and Health

Project partner

Number Name Role Country
1 University Hospital Schleswig-Holstein Coordinator Germany
2 Division of Food Technology Department of Human Nutrition and Food Science Partner Germany
3 University of Calgary Partner Canada
4 Medizinische Universitat Graz Partner Austria