Project: Gut Metabotypes as Biomarkers for Nutrition and Health
WHAT: Health reflects a balanced condition of all our eukaryontic cells and all the microbes living in and on our human body. In contrast, for many different disease entities it has been shown that the host-microbiome axis is dysregulated. Since the gut microbiome is known to be heavily influenced by diet, a balanced and symbiotic interplay between gut bacteria and the human organism might be a promising indicator for nutrition and health. WHO: Our consortium combines two groups with access to large and well characterized human cohorts (Matthias Laudes, Kiel (Germany) and Jane Shearer, Calgary (Canada)) and two well established groups in Metabolomics experienced in liquid chromatography, mass spectrometry (LC-MS) and matrix assisted laser desorption ionization-time of flight (MALDI-TOF) based approaches (Karin Schwarz, Kiel (Germany) and Harald Koefeler, Graz (Austria)). HOW: Identification of bacterial metabolites in the human serum as markers for nutrition and health using a three step program: 1. Identification of biopatterns of gut bacterial metabolites in the human serum, 2. Validation of the identified biopatterns in two independent international cohorts and in the same cohort at different time points, and 3. Verification of the eligibility of the biopatterns as indicators for nutrition and health in two human intervention studies.
Acronym | BioNUGUT (Reference Number: 569) |
Duration | 01/03/2017 - 01/03/2020 |
Network | ERA-HDHL |
Call | Call for Joint Transnational Research Proposals: Biomarkers for Nutrition and Health |
Project partner
Number | Name | Role | Country |
---|---|---|---|
1 | University Hospital Schleswig-Holstein | Coordinator | Germany |
2 | Division of Food Technology Department of Human Nutrition and Food Science | Partner | Germany |
3 | University of Calgary | Partner | Canada |
4 | Medizinische Universitat Graz | Partner | Austria |