Project: Maternal hemodynamics in hypertensive disorders of pregnancy – a human and animal model under antihypertensive therapy

Acronym HyperDiP
Duration 01/05/2019 - 30/04/2021
Project Topic Hypertensive disorders of pregnancy (HDP) are still the leading cause of maternal and neonatal morbidity and mortality worldwide. Recently, a number of studies reported cardiovascular changes in pregnancies affected by HDP suspecting a cardiovascular origin of the disease. Even though there are new insights the concepts of therapy have not changed and evidence for an improvement of antihypertensive therapy (AT) in women with HDP is lacking. Therefore we aim to investigate maternal hemodynamics and cardiovascular parameters in women with HDP compared to a healthy pregnant control group and in a preeclamptic rat model under AT. In this prospective observational case control study over a three-year period we challenge the idea of blood pressure being the suitable target for AT in women with HDP and aim to get new insights into the pathophysiology of preeclampsia by using invasive procedures and assessing the structural morphology of the heart in our rat mode
Network ERA-CVD
Call Joint Transnational Call for Proposal 2018 (JTC 2018)

Project partner

Number Name Role Country
1 Medical University of Vienna Coordinator Austria
2 Oslo University Hospital Ullevål Partner Norway
3 Max-Delbrueck Center for Molecular Medicine Partner Germany