Project: Adaptive Immune Responses in the wounded heart: novel diagnostic and therapeutic opportunities

Acronym AIR-MI
Duration 01/05/2019 - 30/04/2021
Project Topic Myocardial infarction and ensuing ischemic heart disease cause tremendous suffering and economic damage. Despite major advances in their treatment, molecular repair processes in the injured heart remain poorly understood. Consequently, we often cannot identify patients with inadequate repair before heart function deteriorates to a critical stage. Here, we propose that inflammatory processes, particularly T-cell mediated adaptive immune responses, critically regulate early cardiac repair. In our consortium, we will thus dissect T-cell responses in patients suffering from myocardial infarction using cutting-edge technologies such as next generation sequencing and correlate them with clinical outcomes. Further, we will integrate the results with data derived from mechanistic preclinical disease models investigating the role of adaptive immunity in myocardial infarction healing. These experiments will lay the fundament for developing novel immune-based prognostic tools and innovative treatment concepts in patients suffering from myocardial infarction and ischemic heart disease.
Network ERA-CVD
Call Joint Transnational Call for Proposal 2018 (JTC 2018)

Project partner

Number Name Role Country
1 Medical University of Graz Coordinator Austria
2 Sorbonne Université, Partner France
3 University Hospital of Würzburg Partner Germany