Project: “Multiscale modeling of Valvular Heart Diseases. Understanding the mechanisms of adverse remodeling to improve precision medicine”

Acronym SICVALVES (Reference Number: JTC-2019_008)
Duration 01/05/2020 - 30/04/2023
Project Topic Valvular Heart Diseases (VHD) are chronic-rogressive diseases that vary with gender and age. If left untreated, VHDs can cause malignant arrhythmias and severe heart failure. The existing guidelines for treatment are using only rough function parameters that fail to account for inter-individual variability. Nowadays, computational modeling has the potential to unveil important pathophysiological mechanisms and to contribute towards personalized precision medicine. Our objective is to use advanced models of the cell, tissue, and organ level in VHD to gain mechanistic insights about triggers of ventricular arrhythmias, diastolic, and systolic dysfunction and myocardial metabolic alterations and how these processes reinforce each other. Gender differences will be systematically taken into account, to improve diagnostics, risk assessment, and treatment planning of VHDs. Existing models of biomechanics, electrophysiology, and hemodynamics will be optimized for individual cases using a pool of data from our own previous trials. Model parameters will be calibrated under pre- treatment conditions and models will be validated by comparing model predictions of acute post- treatment conditions against clinical data. Finally, longer term follow up data of cases will be used to enable predictions of chronic outcomes.
Network ERA-CVD
Call ERA-CVD Joint Transnational Call 2019

Project partner

Number Name Role Country
1 Medical University of Graz Coordinator Austria
2 University of Bordeaux France
3 Charité - Universitätsmedizin Berlin Germany